Anaemia on Admission is Associated with More Severe Intracerebral Haemorrhage and Worse Outcomes

Background Lower haemoglobin levels may impair cerebral oxygen delivery and threaten tissue viability in the setting of acute brain injury. Few studies have examined the association between haemoglobin levels and outcomes after spontaneous intracerebral haemorrhage. Aims We evaluated whether anaemia...

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Bibliographic Details
Published in:International journal of stroke 2015-04, Vol.10 (3), p.382-387
Main Authors: Bussière, Miguel, Gupta, Meera, Sharma, Mukul, Dowlatshahi, Dar, Fang, Jiming, Dhar, Rajat
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
anaemia
Anemia - epidemiology
Anemia - etiology
Canada
Cerebral Hemorrhage - complications
Cerebral Hemorrhage - mortality
Cohort Studies
Confidence intervals
Female
haemoglobin
Hemoglobins - metabolism
Humans
intracerebral haemorrhage
Male
Medical research
Middle Aged
Odds Ratio
outcomes
Patient Admission - statistics & numerical data
Patient Discharge
Registries
Risk Factors
Severity of Illness Index
Statistics, Nonparametric
Stroke
Treatment Outcome
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Summary:Background Lower haemoglobin levels may impair cerebral oxygen delivery and threaten tissue viability in the setting of acute brain injury. Few studies have examined the association between haemoglobin levels and outcomes after spontaneous intracerebral haemorrhage. Aims We evaluated whether anaemia on admission was associated with greater intracerebral haemorrhage severity and worse outcome. Methods Consecutive patients with spontaneous intracerebral haemorrhage were analyzed from the Registry of the Canadian Stroke Network. Admission haemoglobin was related to stroke severity (using the Canadian Neurological Scale), modified Rankin score at discharge, and one-year mortality. Adjustment was made for potential confounders including age, gender, medical history, warfarin use, glucose, creatinine, blood pressure, and intraventricular haemorrhage. Results Two thousand four hundred six patients with intracerebral haemorrhage were studied of whom 23% had anaemia (haemoglobin
ISSN:1747-4930
1747-4949
DOI:10.1111/j.1747-4949.2012.00951.x