Malignant transformation of craniopharyngioma with detailed follow‐up

A 29‐year‐old male patient was admitted into hospital with the main complaint of progressive visual disturbance. Both CT SCAN and MRI demonstrated a cystic‐solid contrast‐enhancing sellar‐suprasellar mass with obvious calcification. Histopathological examination of the first resected specimen showed...

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Bibliographic Details
Published in:Neuropathology 2015-02, Vol.35 (1), p.50-55
Main Authors: Wang, Wei, Chen, Xiao‐Dong, Bai, Hong‐Min, Liao, Qiu‐Lin, Dai, Xue‐jun, Peng, Da‐Yun, Cao, Hui‐Xia
Format: Article
Language:English
Subjects:
Adult
Cell Transformation, Neoplastic - pathology
craniopharyngioma
Craniopharyngioma - pathology
Follow-Up Studies
follow‐up
Humans
Male
malignant transformation
Pituitary Neoplasms - pathology
prognosis
radiotherapy
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Summary:A 29‐year‐old male patient was admitted into hospital with the main complaint of progressive visual disturbance. Both CT SCAN and MRI demonstrated a cystic‐solid contrast‐enhancing sellar‐suprasellar mass with obvious calcification. Histopathological examination of the first resected specimen showed a typical appearance of adamantinomatous craniopharyngioma. The patient received gamma knife therapy after his first operation because of partial tumor removal. He experienced two relapses in the subsequent 2 years, for which only surgical resection was performed. The later histopathology presented malignant appearance with tumor cells moderate to severe pleomorphism, hyperchromasia, increased nuclear cytoplastic ratio, high mitotic activity (30/10 high power fields) and focal coagulative necrosis. The patient died 9 months after identification of histologic malignancy. Clinical and histopathological features, biological behavior of one case of malignant craniopharyngioma were discussed, with a brief review of the relevant literature.
ISSN:0919-6544
1440-1789
DOI:10.1111/neup.12142