Toll-like receptor 9 promoter polymorphism as a predictive factor of narrow-band UVB phototherapy response in patients with psoriasis

Summary Background Prediction of response to ultraviolet B (UVB) phototherapy in psoriatic patients mainly relies on clinical criteria, although some genetic predictors have been identified. Toll‐like receptors (TLRs) have been involved in psoriasis pathogenesis through activation of the innate immu...

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Published in:Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2015-03, Vol.31 (2), p.98-103
Main Authors: Romaní, Jorge, Julià, Marc, Lozano, Francisco, Muñoz-Santos, Carlos, Guilabert, Antonio, Carrascosa, José M, Rigla, Mercedes, Luelmo, Jesús
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Female
Humans
Male
Middle Aged
phototherapy
Polymorphism, Single Nucleotide
psoriasis
Psoriasis - genetics
Psoriasis - radiotherapy
Severity of Illness Index
toll-like receptor
Toll-Like Receptor 9 - genetics
Ultraviolet Therapy
UVB
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Summary:Summary Background Prediction of response to ultraviolet B (UVB) phototherapy in psoriatic patients mainly relies on clinical criteria, although some genetic predictors have been identified. Toll‐like receptors (TLRs) have been involved in psoriasis pathogenesis through activation of the innate immune system. Their polymorphisms may condition not only the clinical profile of psoriasis but also the response to therapy. Methods We analyzed the role of functional single‐nucleotide polymorphisms (SNPs) of TLR2, 5, 4, and 9 in clinical response to a standard narrow‐band UVB (NBUVB) therapy in 39 patients with moderate to severe psoriasis. Results We found a significant relationship between TLR9‐1486T/C SNP variants and a better response to NBUVB phototherapy. Patients with TC and CC genotype showed a higher improvement of Psoriasis Area and Severity Index (PASI) than patients with TT genotype. Results of multivariate analysis indicate that the differences in PASI improvement at the end of phototherapy attributed to TRL9 SNP genotype were not dependent on the patients' phototype, age, gender, body mass index, basal PASI, or disease evolution. Conclusions We describe a functional genetic variant in TLR9 gene that might affect the susceptibility to antipsoriatic treatment. The search of genetic predictive factors may be helpful in therapy selection and optimization of therapeutic regimes in psoriatic patients.
ISSN:0905-4383
1600-0781
DOI:10.1111/phpp.12160