Loading…

Toll-like receptor 9 promoter polymorphism as a predictive factor of narrow-band UVB phototherapy response in patients with psoriasis

Summary Background Prediction of response to ultraviolet B (UVB) phototherapy in psoriatic patients mainly relies on clinical criteria, although some genetic predictors have been identified. Toll‐like receptors (TLRs) have been involved in psoriasis pathogenesis through activation of the innate immu...

Full description

Saved in:
Bibliographic Details
Published in:Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2015-03, Vol.31 (2), p.98-103
Main Authors: Romaní, Jorge, Julià, Marc, Lozano, Francisco, Muñoz-Santos, Carlos, Guilabert, Antonio, Carrascosa, José M, Rigla, Mercedes, Luelmo, Jesús
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c5060-5174da203feb68f88da23dbb1c732034b9aa4804e25561e52deaa366b7be7ffc3
cites cdi_FETCH-LOGICAL-c5060-5174da203feb68f88da23dbb1c732034b9aa4804e25561e52deaa366b7be7ffc3
container_end_page 103
container_issue 2
container_start_page 98
container_title Photodermatology, photoimmunology & photomedicine
container_volume 31
creator Romaní, Jorge
Julià, Marc
Lozano, Francisco
Muñoz-Santos, Carlos
Guilabert, Antonio
Carrascosa, José M
Rigla, Mercedes
Luelmo, Jesús
description Summary Background Prediction of response to ultraviolet B (UVB) phototherapy in psoriatic patients mainly relies on clinical criteria, although some genetic predictors have been identified. Toll‐like receptors (TLRs) have been involved in psoriasis pathogenesis through activation of the innate immune system. Their polymorphisms may condition not only the clinical profile of psoriasis but also the response to therapy. Methods We analyzed the role of functional single‐nucleotide polymorphisms (SNPs) of TLR2, 5, 4, and 9 in clinical response to a standard narrow‐band UVB (NBUVB) therapy in 39 patients with moderate to severe psoriasis. Results We found a significant relationship between TLR9‐1486T/C SNP variants and a better response to NBUVB phototherapy. Patients with TC and CC genotype showed a higher improvement of Psoriasis Area and Severity Index (PASI) than patients with TT genotype. Results of multivariate analysis indicate that the differences in PASI improvement at the end of phototherapy attributed to TRL9 SNP genotype were not dependent on the patients' phototype, age, gender, body mass index, basal PASI, or disease evolution. Conclusions We describe a functional genetic variant in TLR9 gene that might affect the susceptibility to antipsoriatic treatment. The search of genetic predictive factors may be helpful in therapy selection and optimization of therapeutic regimes in psoriatic patients.
doi_str_mv 10.1111/phpp.12160
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1668259394</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1664192911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5060-5174da203feb68f88da23dbb1c732034b9aa4804e25561e52deaa366b7be7ffc3</originalsourceid><addsrcrecordid>eNqNkc9u1DAQhy1URJfChQdAPlZIKXb8J8mxrWAXqZQ9bNmj5SQTxW0SG9vLsg_Q96632_aI6oOtGX_zSaMfQp8oOaPpfHW9c2c0p5K8QbN0k4wUJT1CM1IRkXFWsmP0PoRbQgjnhL5Dx7kQkhJBZ-h-ZYchG8wdYA8NuGg9rrDzdrQRPHZ22I3Wu96EEeuAdfqC1jTR_AXc6WaP2w5P2nu7zWo9tfjm9wV2vY029uC12yVvcHYKgM2EnY4Gphjw1sQeu2C90cGED-htp4cAH5_eE3Tz_dvqcpFd_Zr_uDy_yhpBJMkELXirc8I6qGXZlWUqWFvXtClY6vK60pqXhMPjfiDyFrRmUtZFDUXXNewEnR68acE_GwhRjSY0MAx6ArsJikpZ5qJiFX8NymmVV5Qm9MsBbbwNwUOnnDej9jtFidonpPYJqceEEvz5ybupR2hf0OdIEkAPwNYMsPuPSi0Xy-WzNDvMmBDh38uM9ndKFqwQan09V-Xqgi3W87X6yR4A8xGtSw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1664192911</pqid></control><display><type>article</type><title>Toll-like receptor 9 promoter polymorphism as a predictive factor of narrow-band UVB phototherapy response in patients with psoriasis</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Romaní, Jorge ; Julià, Marc ; Lozano, Francisco ; Muñoz-Santos, Carlos ; Guilabert, Antonio ; Carrascosa, José M ; Rigla, Mercedes ; Luelmo, Jesús</creator><creatorcontrib>Romaní, Jorge ; Julià, Marc ; Lozano, Francisco ; Muñoz-Santos, Carlos ; Guilabert, Antonio ; Carrascosa, José M ; Rigla, Mercedes ; Luelmo, Jesús</creatorcontrib><description>Summary Background Prediction of response to ultraviolet B (UVB) phototherapy in psoriatic patients mainly relies on clinical criteria, although some genetic predictors have been identified. Toll‐like receptors (TLRs) have been involved in psoriasis pathogenesis through activation of the innate immune system. Their polymorphisms may condition not only the clinical profile of psoriasis but also the response to therapy. Methods We analyzed the role of functional single‐nucleotide polymorphisms (SNPs) of TLR2, 5, 4, and 9 in clinical response to a standard narrow‐band UVB (NBUVB) therapy in 39 patients with moderate to severe psoriasis. Results We found a significant relationship between TLR9‐1486T/C SNP variants and a better response to NBUVB phototherapy. Patients with TC and CC genotype showed a higher improvement of Psoriasis Area and Severity Index (PASI) than patients with TT genotype. Results of multivariate analysis indicate that the differences in PASI improvement at the end of phototherapy attributed to TRL9 SNP genotype were not dependent on the patients' phototype, age, gender, body mass index, basal PASI, or disease evolution. Conclusions We describe a functional genetic variant in TLR9 gene that might affect the susceptibility to antipsoriatic treatment. The search of genetic predictive factors may be helpful in therapy selection and optimization of therapeutic regimes in psoriatic patients.</description><identifier>ISSN: 0905-4383</identifier><identifier>EISSN: 1600-0781</identifier><identifier>DOI: 10.1111/phpp.12160</identifier><identifier>PMID: 25561051</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; phototherapy ; Polymorphism, Single Nucleotide ; psoriasis ; Psoriasis - genetics ; Psoriasis - radiotherapy ; Severity of Illness Index ; toll-like receptor ; Toll-Like Receptor 9 - genetics ; Ultraviolet Therapy ; UVB</subject><ispartof>Photodermatology, photoimmunology &amp; photomedicine, 2015-03, Vol.31 (2), p.98-103</ispartof><rights>2014 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd</rights><rights>2014 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5060-5174da203feb68f88da23dbb1c732034b9aa4804e25561e52deaa366b7be7ffc3</citedby><cites>FETCH-LOGICAL-c5060-5174da203feb68f88da23dbb1c732034b9aa4804e25561e52deaa366b7be7ffc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25561051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romaní, Jorge</creatorcontrib><creatorcontrib>Julià, Marc</creatorcontrib><creatorcontrib>Lozano, Francisco</creatorcontrib><creatorcontrib>Muñoz-Santos, Carlos</creatorcontrib><creatorcontrib>Guilabert, Antonio</creatorcontrib><creatorcontrib>Carrascosa, José M</creatorcontrib><creatorcontrib>Rigla, Mercedes</creatorcontrib><creatorcontrib>Luelmo, Jesús</creatorcontrib><title>Toll-like receptor 9 promoter polymorphism as a predictive factor of narrow-band UVB phototherapy response in patients with psoriasis</title><title>Photodermatology, photoimmunology &amp; photomedicine</title><addtitle>Photodermatol. Photoimmunol. Photomed</addtitle><description>Summary Background Prediction of response to ultraviolet B (UVB) phototherapy in psoriatic patients mainly relies on clinical criteria, although some genetic predictors have been identified. Toll‐like receptors (TLRs) have been involved in psoriasis pathogenesis through activation of the innate immune system. Their polymorphisms may condition not only the clinical profile of psoriasis but also the response to therapy. Methods We analyzed the role of functional single‐nucleotide polymorphisms (SNPs) of TLR2, 5, 4, and 9 in clinical response to a standard narrow‐band UVB (NBUVB) therapy in 39 patients with moderate to severe psoriasis. Results We found a significant relationship between TLR9‐1486T/C SNP variants and a better response to NBUVB phototherapy. Patients with TC and CC genotype showed a higher improvement of Psoriasis Area and Severity Index (PASI) than patients with TT genotype. Results of multivariate analysis indicate that the differences in PASI improvement at the end of phototherapy attributed to TRL9 SNP genotype were not dependent on the patients' phototype, age, gender, body mass index, basal PASI, or disease evolution. Conclusions We describe a functional genetic variant in TLR9 gene that might affect the susceptibility to antipsoriatic treatment. The search of genetic predictive factors may be helpful in therapy selection and optimization of therapeutic regimes in psoriatic patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>phototherapy</subject><subject>Polymorphism, Single Nucleotide</subject><subject>psoriasis</subject><subject>Psoriasis - genetics</subject><subject>Psoriasis - radiotherapy</subject><subject>Severity of Illness Index</subject><subject>toll-like receptor</subject><subject>Toll-Like Receptor 9 - genetics</subject><subject>Ultraviolet Therapy</subject><subject>UVB</subject><issn>0905-4383</issn><issn>1600-0781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkc9u1DAQhy1URJfChQdAPlZIKXb8J8mxrWAXqZQ9bNmj5SQTxW0SG9vLsg_Q96632_aI6oOtGX_zSaMfQp8oOaPpfHW9c2c0p5K8QbN0k4wUJT1CM1IRkXFWsmP0PoRbQgjnhL5Dx7kQkhJBZ-h-ZYchG8wdYA8NuGg9rrDzdrQRPHZ22I3Wu96EEeuAdfqC1jTR_AXc6WaP2w5P2nu7zWo9tfjm9wV2vY029uC12yVvcHYKgM2EnY4Gphjw1sQeu2C90cGED-htp4cAH5_eE3Tz_dvqcpFd_Zr_uDy_yhpBJMkELXirc8I6qGXZlWUqWFvXtClY6vK60pqXhMPjfiDyFrRmUtZFDUXXNewEnR68acE_GwhRjSY0MAx6ArsJikpZ5qJiFX8NymmVV5Qm9MsBbbwNwUOnnDej9jtFidonpPYJqceEEvz5ybupR2hf0OdIEkAPwNYMsPuPSi0Xy-WzNDvMmBDh38uM9ndKFqwQan09V-Xqgi3W87X6yR4A8xGtSw</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Romaní, Jorge</creator><creator>Julià, Marc</creator><creator>Lozano, Francisco</creator><creator>Muñoz-Santos, Carlos</creator><creator>Guilabert, Antonio</creator><creator>Carrascosa, José M</creator><creator>Rigla, Mercedes</creator><creator>Luelmo, Jesús</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201503</creationdate><title>Toll-like receptor 9 promoter polymorphism as a predictive factor of narrow-band UVB phototherapy response in patients with psoriasis</title><author>Romaní, Jorge ; Julià, Marc ; Lozano, Francisco ; Muñoz-Santos, Carlos ; Guilabert, Antonio ; Carrascosa, José M ; Rigla, Mercedes ; Luelmo, Jesús</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5060-5174da203feb68f88da23dbb1c732034b9aa4804e25561e52deaa366b7be7ffc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>phototherapy</topic><topic>Polymorphism, Single Nucleotide</topic><topic>psoriasis</topic><topic>Psoriasis - genetics</topic><topic>Psoriasis - radiotherapy</topic><topic>Severity of Illness Index</topic><topic>toll-like receptor</topic><topic>Toll-Like Receptor 9 - genetics</topic><topic>Ultraviolet Therapy</topic><topic>UVB</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romaní, Jorge</creatorcontrib><creatorcontrib>Julià, Marc</creatorcontrib><creatorcontrib>Lozano, Francisco</creatorcontrib><creatorcontrib>Muñoz-Santos, Carlos</creatorcontrib><creatorcontrib>Guilabert, Antonio</creatorcontrib><creatorcontrib>Carrascosa, José M</creatorcontrib><creatorcontrib>Rigla, Mercedes</creatorcontrib><creatorcontrib>Luelmo, Jesús</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Photodermatology, photoimmunology &amp; photomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romaní, Jorge</au><au>Julià, Marc</au><au>Lozano, Francisco</au><au>Muñoz-Santos, Carlos</au><au>Guilabert, Antonio</au><au>Carrascosa, José M</au><au>Rigla, Mercedes</au><au>Luelmo, Jesús</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toll-like receptor 9 promoter polymorphism as a predictive factor of narrow-band UVB phototherapy response in patients with psoriasis</atitle><jtitle>Photodermatology, photoimmunology &amp; photomedicine</jtitle><addtitle>Photodermatol. Photoimmunol. Photomed</addtitle><date>2015-03</date><risdate>2015</risdate><volume>31</volume><issue>2</issue><spage>98</spage><epage>103</epage><pages>98-103</pages><issn>0905-4383</issn><eissn>1600-0781</eissn><abstract>Summary Background Prediction of response to ultraviolet B (UVB) phototherapy in psoriatic patients mainly relies on clinical criteria, although some genetic predictors have been identified. Toll‐like receptors (TLRs) have been involved in psoriasis pathogenesis through activation of the innate immune system. Their polymorphisms may condition not only the clinical profile of psoriasis but also the response to therapy. Methods We analyzed the role of functional single‐nucleotide polymorphisms (SNPs) of TLR2, 5, 4, and 9 in clinical response to a standard narrow‐band UVB (NBUVB) therapy in 39 patients with moderate to severe psoriasis. Results We found a significant relationship between TLR9‐1486T/C SNP variants and a better response to NBUVB phototherapy. Patients with TC and CC genotype showed a higher improvement of Psoriasis Area and Severity Index (PASI) than patients with TT genotype. Results of multivariate analysis indicate that the differences in PASI improvement at the end of phototherapy attributed to TRL9 SNP genotype were not dependent on the patients' phototype, age, gender, body mass index, basal PASI, or disease evolution. Conclusions We describe a functional genetic variant in TLR9 gene that might affect the susceptibility to antipsoriatic treatment. The search of genetic predictive factors may be helpful in therapy selection and optimization of therapeutic regimes in psoriatic patients.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25561051</pmid><doi>10.1111/phpp.12160</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0905-4383
ispartof Photodermatology, photoimmunology & photomedicine, 2015-03, Vol.31 (2), p.98-103
issn 0905-4383
1600-0781
language eng
recordid cdi_proquest_miscellaneous_1668259394
source Wiley-Blackwell Read & Publish Collection
subjects Adolescent
Adult
Aged
Female
Humans
Male
Middle Aged
phototherapy
Polymorphism, Single Nucleotide
psoriasis
Psoriasis - genetics
Psoriasis - radiotherapy
Severity of Illness Index
toll-like receptor
Toll-Like Receptor 9 - genetics
Ultraviolet Therapy
UVB
title Toll-like receptor 9 promoter polymorphism as a predictive factor of narrow-band UVB phototherapy response in patients with psoriasis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T02%3A31%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Toll-like%20receptor%209%20promoter%20polymorphism%20as%20a%20predictive%20factor%20of%20narrow-band%20UVB%20phototherapy%20response%20in%20patients%20with%20psoriasis&rft.jtitle=Photodermatology,%20photoimmunology%20&%20photomedicine&rft.au=Roman%C3%AD,%20Jorge&rft.date=2015-03&rft.volume=31&rft.issue=2&rft.spage=98&rft.epage=103&rft.pages=98-103&rft.issn=0905-4383&rft.eissn=1600-0781&rft_id=info:doi/10.1111/phpp.12160&rft_dat=%3Cproquest_cross%3E1664192911%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5060-5174da203feb68f88da23dbb1c732034b9aa4804e25561e52deaa366b7be7ffc3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1664192911&rft_id=info:pmid/25561051&rfr_iscdi=true