Manifestations of Perihepatic Lymph Nodes in Acute Flare of Chronic Hepatitis B: Association with HBeAg Status and with HBeAg Seroconversion: e0117590

It has been observed that enlargement of perihepatic lymph nodes may be seen in patients with chronic hepatitis B, particularly during acute flares of CHB. We hypothesized that there may be a correlation between the nodal change patterns in CHB patients with acute flare and HBeAg status. Perihepatic...

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Published in:PloS one 2015-02, Vol.10 (2)
Main Authors: Ko, Yen-Ling, Sun, Chi-Shu, Chung, Kun-Ming, Lin, Yu-Min, Feng, I-Che, Sheu, Ming-Jen, Koay, Lok-Beng, Lin, Ching-Yih, Ho, Chung-Han, Kuo, Hsing-Tao
Format: Article
Language:English
Subjects:
Hepatitis B virus
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Summary:It has been observed that enlargement of perihepatic lymph nodes may be seen in patients with chronic hepatitis B, particularly during acute flares of CHB. We hypothesized that there may be a correlation between the nodal change patterns in CHB patients with acute flare and HBeAg status. Perihepatic lymph node sizes of 87 patients with acute flares of CHB were documented, with a median follow up of 43 months. Patients were separated into 3 groups, HBeAg-positive with HBe seroconversion (group 1), HBeAg-positive without HBe seroconversion (group 2), and HBeAg-negative (group 3). Group 1 has the highest incidence of enlarged lymph nodes (92.3%) compared with group 2 (75.8%) and group 3 (46.8%) (p = 0.003). And if nodal width at acute flare was > 8mm and interval change of nodal width was >3mm, the incidence of HBeAg seroconversion will be 75% (p
ISSN:1932-6203
DOI:10.1371/journal.pone.0117590