Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in patients with endometrial hyperplasia and endometrial cancer

• Published in: The journal of obstetrics and gynaecology research 2015-03, Vol.41 (3), p.445-448
• Main Authors: Ural, Ülkü Mete, Şehitoğlu, İbrahim, Tekin, Yeşim Bayoğlu, Şahin, Figen Kir
• Format: Article
• Language: English
• Subjects: Adenocarcinoma, Mucinous - blood; Adult; Aged; Blood Platelets - pathology; Carcinoma, Endometrioid - blood; Carcinoma, Papillary - blood; endometrial cancer; endometrial hyperplasia; Endometrial Hyperplasia - blood; Endometrial Neoplasms - blood; Female; Humans; Lymphocyte Count; Lymphocytes; Middle Aged; neutrophil-to-lymphocyte ratio; Neutrophils; Platelet Count; platelet distribution width; platelet-to-lymphocyte ratio
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.12536

Aim Neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR) and platelet distribution width (PDW) may indicate the systemic inflammatory response associated with various cancers. We aimed to investigate the relationship between NLR, PLR, PDW and endometrial pathologies including hyperplasia and cancer. Methods In this study, 472 cases who underwent endometrial biopsy were included. Three groups were constituted with respect to biopsy results: group 1, endometrial cancer patients (n = 54); group 2, endometrial hyperplasia patients (n = 152); and group 3, patients with normal biopsy results (n = 281). White blood cell and platelet counts as well as NLR, PLR and PDW recorded from complete blood counts obtained on the same day of biopsy were compared in the three groups. Results Endometrial cancer patients were significantly older than the cases in the other two groups (P