Nuclear reprogramming and induced pluripotent stem cells: a review for surgeons

Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the exogenous expression of defined transcription factors. iPSCs share the defining features of embryonic stem cells (ESCs) in that they are able to self renew indefinitely and maintain the potential to develop into all cell...

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Bibliographic Details
Published in:ANZ journal of surgery 2014-06, Vol.84 (6), p.417-423
Main Authors: Qi, Sara D., Smith, Paul D., Choong, Peter F.
Format: Article
Language:English
Subjects:
Cellular Reprogramming - physiology
Embryonic Stem Cells - cytology
Embryos
Female
Forecasting
Humans
induced pluripotent stem cell
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - transplantation
Male
Medical ethics
Medical technology
nuclear reprogramming
Quality Improvement
regenerative medicine
Regenerative Medicine - methods
stem cell
Stem Cell Transplantation - methods
Stem cells
Surgeons
Surgery
Transplants & implants
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Description
Summary:Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the exogenous expression of defined transcription factors. iPSCs share the defining features of embryonic stem cells (ESCs) in that they are able to self renew indefinitely and maintain the potential to develop into all cell types of the body. These cells have key advantages over ESCs in that they are autologous to the donor cells and can be generated from individuals at any age. iPSCs also circumvent ethical and political issues surrounding the destruction of embryos that is necessary in the isolation of ESCs. This review briefly describes the advent of iPSC technology and the concepts of nuclear reprogramming, and discusses the potential application of this powerful biological tool in both surgical research and regenerative medicine.
ISSN:1445-1433
1445-2197
DOI:10.1111/ans.12419