Temporal and regional variations in sporadic Creutzfeldt–Jakob disease in Japan, 2001–2010

The objective of this study was to examine temporal and regional variations of sporadic Creutzfeldt–Jakob disease (sCJD) in a retrospective study using Japanese national surveillance data from 2001 to 2010. We calculated the incidence of sCJD by age and sex, derived the standardized incidence in eac...

Full description

Saved in:
Bibliographic Details
Published in:Epidemiology and infection 2015-04, Vol.143 (5), p.1073-1078
Main Authors: NAKATANI, E., NISHIMURA, T., ZHOU, B., KANEDA, H., TERAMUKAI, S., NAGAI, Y., FUKUSHIMA, M., KANATANI, Y.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Age groups
Aged
Annual reports
Child
Child, Preschool
Creutzfeldt-Jakob disease
Creutzfeldt-Jakob Syndrome - epidemiology
Dementia
Electroencephalography
Epidemiology
Female
Gender differences
Humans
Iatrogenesis
Incidence
Infant
Infant, Newborn
Investigations
Japan - epidemiology
Male
Middle Aged
Mortality
Original Papers
Retrospective Studies
Sex Distribution
Statistical analysis
Time Factors
Women
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of this study was to examine temporal and regional variations of sporadic Creutzfeldt–Jakob disease (sCJD) in a retrospective study using Japanese national surveillance data from 2001 to 2010. We calculated the incidence of sCJD by age and sex, derived the standardized incidence in each of the 47 prefectures, and performed spatial disease clustering analysis. The average annual incidence of sCJD was 1·026 per million in men (637 patients) and 1·132 per million in women (733 patients), a significant sex difference after adjustment for age (P = 0·001). The ratios of familial CJD to sCJD apparently increased between 2001–2005 and 2006–2010, possibly as a result of the nationwide introduction of genetic testing after 2006. Based on the data of 2006–2010, certain geographical clusters of sCJD were identified. The incidence of sCJD was higher in several specific prefectures compared to the national average. Thus, sCJD appears to have regional variations, suggesting the existence of genetic or region-specific factors affecting the incidence of the disease.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268814001605