Successful Treatment of Paecilomyces variotii Peritonitis in a Liver Transplant Patient

Paecilomyces variotii has previously been reported as a causative pathogen for peritonitis in patients on continuous ambulatory peritoneal dialysis and shown to be usually sensitive to amphotericin B and resistant to voriconazole. We report the first case, to our knowledge, of P. variotii peritoniti...

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Bibliographic Details
Published in:Mycopathologia (1975) 2015-04, Vol.179 (3-4), p.317-320
Main Authors: Polat, Meltem, Kara, Soner Sertan, Tapısız, Anıl, Demirtaş, Zeliha, Sarı, Sinan, Kalkancı, Ayşe, Tezer, Hasan, Dalgıç, Buket
Format: Article
Language:English
Subjects:
Abdomen
Adolescent
Amphotericin B
Antifungal Agents - administration & dosage
Antiparasitic agents
Bile
Biomedical and Life Sciences
Blood
Care and treatment
Catheters
Eukaryotic Microbiology
Fever
Health aspects
Hemodialysis
Humans
Infection
Infections
Laboratories
Life Sciences
Liver transplantation
Liver Transplantation - adverse effects
Liver transplants
Male
Medical Microbiology
Microbial Ecology
Microbiology
Morphology
Mycoses - drug therapy
Mycoses - microbiology
Paecilomyces - drug effects
Paecilomyces - genetics
Paecilomyces - isolation & purification
Paecilomyces variotii
Pathogens
Patients
Pediatrics
Peritoneal dialysis
Peritonitis
Peritonitis - drug therapy
Peritonitis - microbiology
Plant Sciences
Postoperative Complications - drug therapy
Postoperative Complications - microbiology
Voriconazole - administration & dosage
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Summary:Paecilomyces variotii has previously been reported as a causative pathogen for peritonitis in patients on continuous ambulatory peritoneal dialysis and shown to be usually sensitive to amphotericin B and resistant to voriconazole. We report the first case, to our knowledge, of P. variotii peritonitis in a liver transplant patient, which was unresponsive to initial liposomal amphotericin B (L-AmB) treatment and resolved dramatically after the addition of voriconazole. The present case provides evidence for the clinical and microbiological effectiveness of voriconazole combined with L-AmB in treating P. variotii peritonitis refractory to initial L-AmB treatment.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-014-9854-1