Pulmonary Inflammation in Foundry Workers

OBJECTIVE:To assess whether cumulative dust exposure in foundry work is associated with airway inflammation measured by the analysis of fractionated exhaled nitric oxide (NO) concentration, or by inflammatory markers in exhaled breath condensate or serum. METHODS:We examined 476 dust-exposed and non...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine 2015-02, Vol.57 (2), p.124-128
Main Authors: Koskela, Kirsi, Oksa, Panu, Sauni, Riitta, Linnainmaa, Markku, Toivio, Pauliina, Lehtimäki, Lauri, Moilanen, Eeva, Nieminen, Riina, Luukkonen, Ritva, Uitti, Jukka
Format: Article
Language:English
Subjects:
Adult
Biomarkers - analysis
Breath Tests
Bronchiolitis - etiology
Bronchiolitis - metabolism
C-Reactive Protein - metabolism
Cross-Sectional Studies
Dust
Dust - analysis
Foundries
Human exposure
Humans
Interleukin-8 - blood
Lung Diseases, Interstitial - etiology
Lung Diseases, Interstitial - metabolism
Male
Metallurgy
Middle Aged
Nitric oxide
Nitric Oxide - metabolism
Occupational Exposure - adverse effects
Occupational Exposure - analysis
Occupational health
Original Article
Workers
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Summary:OBJECTIVE:To assess whether cumulative dust exposure in foundry work is associated with airway inflammation measured by the analysis of fractionated exhaled nitric oxide (NO) concentration, or by inflammatory markers in exhaled breath condensate or serum. METHODS:We examined 476 dust-exposed and nonexposed foundry workers, and assessed the individual cumulative exposure to dusts and respirable quartz. Bronchial and alveolar NO production and inflammatory markers in exhaled breath condensate and in serum samples were also analyzed. RESULTS:After adjusting for pack-years of smoking, increased levels of alveolar NO, serum C-reactive protein, and interleukin-8 were associated with a higher level of cumulative exposure to dust. The referents had higher serum myeloperoxidase levels, bronchial NO output, and 8-isoprostane levels in exhaled breath condensate than in the dust-exposed groups. CONCLUSIONS:Dust exposure in foundry work may induce both systemic and alveolar inflammation.
ISSN:1076-2752
1536-5948
DOI:10.1097/JOM.0000000000000390