The relaxin family peptide receptors and their ligands: New developments and paradigms in the evolution from jawless fish to mammals

Highlights • The origin of Rln/Insl-Rxfp systems probably dates back to the divergence of cephalochordates. • The ancient signaling system consisted of 1 ligand interacting with 2 divergent receptors. • The system predominantly diversified via whole genome duplications in vertebrates. • Differential...

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Bibliographic Details
Published in:General and comparative endocrinology 2014-12, Vol.209, p.93-105
Main Authors: Yegorov, Sergey, Bogerd, Jan, Good, Sara V
Format: Article
Language:English
Subjects:
Animals
Biological Evolution
Endocrinology & Metabolism
Fishes - genetics
Gene nomenclature
GPCR evolution
Humans
Insulin superfamily
Ligands
Mammals - genetics
Multigene Family
Petromyzontidae
Phylogenetics
Phylogeny
Receptors, G-Protein-Coupled - chemistry
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - physiology
Receptors, Peptide - chemistry
Receptors, Peptide - genetics
Receptors, Peptide - physiology
Relaxin - chemistry
Relaxin - genetics
Relaxin - physiology
Relaxin and insulin-like peptides
Relaxin family peptide receptors (RXFP)
Structure-Activity Relationship
Teleostei
Whole genome duplication
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Summary:Highlights • The origin of Rln/Insl-Rxfp systems probably dates back to the divergence of cephalochordates. • The ancient signaling system consisted of 1 ligand interacting with 2 divergent receptors. • The system predominantly diversified via whole genome duplications in vertebrates. • Differential gene loss and selection has occurred across vertebrates lineages. • A revised nomenclature incorporating all vertebrate genes is proposed.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2014.07.014