Release from quiescence of CD34 super(+) CD38 super(-) human umbilical cord blood cells reveals their potentiality to engraft adults

Using optimal culture conditions in which the transforming growth factor beta 1 (TGF- beta 1) inhibitory loop has been interrupted by antisense TGF- beta 1 oligonucleotides or anti-TGF- beta serum, we have compared the proliferative capacities and the abilities of the CD34 super(+) CD38 super(-) cel...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1993-01, Vol.90 (18), p.8707-8711
Main Authors: Cardoso, A A, Li, Ma-Lin, Batard, P, Hatzfeld, A, Levesque, J-P, Sookdeo, H, Panterne, B, Sansilvestri, P, Hatzfeld, J
Format: Article
Language:English
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Summary:Using optimal culture conditions in which the transforming growth factor beta 1 (TGF- beta 1) inhibitory loop has been interrupted by antisense TGF- beta 1 oligonucleotides or anti-TGF- beta serum, we have compared the proliferative capacities and the abilities of the CD34 super(+) CD38 super(-) cell populations from bone marrow and umbilical cord blood to generate early progenitors in long-term cultures. These studies suggest that umbilical cord blood is a suitable source of cells for adult transplantation.
ISSN:0027-8424