Entrapment of reagents in polymeric materials. Indirect atomic absorption spectrometric determination of isoniazid by oxidation with manganese dioxide incorporated in polyester resin beads in a flow-injection system

A method for entrapment of reagents is described. The experimental procedure is based on the dispersion of the reagent (MnO 2) into an unsaturated polyester solution and grinding the product to give the required particle size (300–400 μm). The reagent is packed into a bed reactor (1.5 mm i.d.) and i...

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Bibliographic Details
Published in:Analytica chimica acta 1992-08, Vol.265 (1), p.81-86
Main Authors: Lahuerta Zamora, L., Garcia Mateo, J.V., Martinez Calatayud, J.
Format: Article
Language:English
Subjects:
Atomic absorption spectrometry
Flow injection
Isoniazid
Pharmaceutical
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Summary:A method for entrapment of reagents is described. The experimental procedure is based on the dispersion of the reagent (MnO 2) into an unsaturated polyester solution and grinding the product to give the required particle size (300–400 μm). The reagent is packed into a bed reactor (1.5 mm i.d.) and incorporated in a flow-injection system. The procedure was used for the indirect atomic absorption spectrometric determination of isoniazid (0.5–10 μg ml −1) in solutions of pharmaceutical products, with little interference from excipients. The measurements are based on the determination of Mn 2+ released on oxidation of the isoniazid. The relative standard deviation for the determination of 5 μg ml −1 of isoniazid is 2.57% ( n = 40) and the sample throughput is 43 h −1.
ISSN:0003-2670
1873-4324
DOI:10.1016/0003-2670(92)85157-2