Association of adulthood weight gain with circulating adipokine and insulin resistance in the Japanese population

Background/Objectives: Although adipokines and insulin resistance are known to be correlated with body fatness, it is unclear whether they are independently related to weight gain experience. We examined the associations of serum adipokines and marker of insulin resistance with past weight gain duri...

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Bibliographic Details
Published in:European journal of clinical nutrition 2015-04, Vol.69 (4), p.462-466
Main Authors: Kimura, Y, Pham, N M, Yasuda, K, Nanri, A, Kurotani, K, Kuwahara, K, Akter, S, Sato, M, Hayabuchi, H, Mizoue, T
Format: Article
Language:English
Subjects:
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Adiponectin
Adiponectin - blood
Adipose Tissue - metabolism
Adult
Asian Continental Ancestry Group
Biomarkers - blood
Body Mass Index
Body size
Body weight gain
Clinical Nutrition
Cross-Sectional Studies
Cytokines
Epidemiology
Female
Homeostasis
Hormones
Humans
Insulin
Insulin Resistance
Internal Medicine
Leptin
Leptin - blood
Levels
Life Style
Linear Models
Male
Medical research
Medicine
Medicine & Public Health
Metabolic Diseases
Nicotinamide Phosphoribosyltransferase - blood
original-article
Plasminogen Activator Inhibitor 1 - blood
Plasminogen activator inhibitors
Public Health
Resistin - blood
Weight
Weight Gain
Young Adult
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Summary:Background/Objectives: Although adipokines and insulin resistance are known to be correlated with body fatness, it is unclear whether they are independently related to weight gain experience. We examined the associations of serum adipokines and marker of insulin resistance with past weight gain during adulthood by taking the degree of attained body mass index (BMI) level into consideration. Subjects/Methods: Subjects were 399 Japanese municipal employees, aged ⩾30 years, who participated in a health survey. Serum adipokines were measured using a Luminex suspension bead-based multiplexed array. Weight change during adulthood was calculated as the difference between measured current weight and recalled weight at the age of 20 years. Multiple regression was performed to calculate mean adipokine levels and homeostasis model assessment of insulin resistance (HOMA-IR) according to weight gain (
ISSN:0954-3007
1476-5640
DOI:10.1038/ejcn.2014.257