Investigation of possible toxicological influences of simmondsin after subacute administration in the rat

A 5-day administration of 250 mg of simmondsin/kg of body weight did not have any toxicological influences on liver, pancreas, and kidneys using several biochemical parameters. Anatomopathological investigation of kidney, liver, pancreas, stomach, intestine, testis, and seminal vesicle also did not...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1992-12, Vol.40 (12), p.2443-2445
Main Authors: Cokelaere, Marnix M, Dangreau, Hugo D, Daenens, Paul, Bruneel, Noel, Arnouts, Sven, Decuypere, Eddy M. P, Kuhn, Eduard R
Format: Article
Language:English
Subjects:
Biological and medical sciences
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
FITOTOXICIDAD
GLUCOSIDE
GLUCOSIDOS
INGESTION DE ALIMENTOS
INHIBICION
INHIBITION
Medical sciences
METHODE D'APPLICATION
METODOS DE APLICACION
PESO
PHYTOTOXICITE
Plant poisons toxicology
PLASMA SANGUIN
PLASMA SANGUINEO
POIDS
PRISE ALIMENTAIRE (HOMME)
PURIFICACION
PURIFICATION
SIMMONDSIA CHINENSIS
Toxicology
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Summary:A 5-day administration of 250 mg of simmondsin/kg of body weight did not have any toxicological influences on liver, pancreas, and kidneys using several biochemical parameters. Anatomopathological investigation of kidney, liver, pancreas, stomach, intestine, testis, and seminal vesicle also did not demonstrate any pathological change. Since the concentrations of CN- and of SCN- in the blood are not elevated, it is concluded that there are no indications for a liberation of HCN during the metabolism of simmondsin in the rat. The food intake inhibition and weight-reducing effect of gastrally intubated simmondsin in rats has been confirmed, but there are no indications that HCN causes the food intake reduction or the weight loss after simmondsin intake in rats
ISSN:0021-8561
1520-5118
DOI:10.1021/jf00024a020