The effect of R-(-)-deprenyl administration on reproductive parameters of rat males

The aim of the study was to investigate the effect of R-(-)-deprenyl administration on the reproductive parameters of rat males. After 30 days of intraperitoneal administration of saline or 0.0025mg/kg (10−5mol/l) of R-(-)-deprenyl dissolved in saline, males were mated with females of the same strai...

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Published in:European journal of pharmacology 2015-05, Vol.754, p.148-152
Main Authors: Mihalik, Jozef, Mašlanková, Jana, Solár, Peter, Horváthová, Františka, Hubková, Beáta, Almášiová, Viera, Šoltés, Ján, Švaňa, Martin, Rybárová, Silvia, Hodorová, Ingrid
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
DNA Fragmentation - drug effects
Epididymis - drug effects
Female
Fertility - drug effects
Follicle Stimulating Hormone - blood
FSH
Luteinizing Hormone - blood
Male
Monoamine Oxidase Inhibitors - adverse effects
Rats
Reproduction - drug effects
Selegiline
Selegiline - adverse effects
Spermatozoa - drug effects
TAS
Testosterone
Testosterone - blood
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Summary:The aim of the study was to investigate the effect of R-(-)-deprenyl administration on the reproductive parameters of rat males. After 30 days of intraperitoneal administration of saline or 0.0025mg/kg (10−5mol/l) of R-(-)-deprenyl dissolved in saline, males were mated with females of the same strain. Subsequently, animals were killed by thiopental, and their blood and sperm were collected. We found that epididymis of males exposed to R-(-)-deprenyl had higher sperm count (P
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2015.02.030