Telomere shortening in mucosa surrounding the tumor: Biosensor of field cancerization and prognostic marker of mucosal failure in head and neck squamous cell carcinoma

Highlights • Evaluation of telomere length and levels of TERT in cancer tissues and tumor surrounding mucosa (SM). • No correlation was found between age and telomere length in SM. • Patients with short telomeres in SM had a significantly higher risk of mucosal failure. • Patients with high TERT lev...

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Bibliographic Details
Published in:Oral oncology 2015-05, Vol.51 (5), p.500-507
Main Authors: Boscolo-Rizzo, Paolo, Rampazzo, Enrica, Perissinotto, Egle, Piano, Maria Assunta, Giunco, Silvia, Baboci, Lorena, Spinato, Giacomo, Spinato, Roberto, Tirelli, Giancarlo, Da Mosto, Maria Cristina, Del Mistro, Annarosa, De Rossi, Anita
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
Biosensing Techniques
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Field cancerization
Head and neck cancer
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - pathology
Hematology, Oncology and Palliative Medicine
Human papilloma virus
Humans
Local relapse
Molecular biology
Mucous Membrane - metabolism
Otolaryngology
Prognosis
Survival
Telomerase - metabolism
Telomerase reverse transcriptase
Telomere
Telomeres
TERT
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Summary:Highlights • Evaluation of telomere length and levels of TERT in cancer tissues and tumor surrounding mucosa (SM). • No correlation was found between age and telomere length in SM. • Patients with short telomeres in SM had a significantly higher risk of mucosal failure. • Patients with high TERT levels in cancer tissues had a significantly higher risk of regional failure. • Telomere erosion is a biosensor of field cancerization and precedes the reactivation of TERT in SM.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2015.02.100