A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage

Abstract There is no effective treatment for intracerebral hemorrhage (ICH). Intracerebral delivery of nanomaterials into the hemorrhagic lesion may be a new therapeutic strategy. In a rat model of ICH plus ultra-early hematoma aspiration, we found that locally delivered self-assembling peptide nano...

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Bibliographic Details
Published in:Nanomedicine 2015-04, Vol.11 (3), p.611-620
Main Authors: Sang, Lynn Yan-Hua, PhD, Liang, Yu-Xiang, PhD, Li, Yue, PhD, Wong, Wai-Man, MSc, Tay, David Kiong-Chiu, PhD, So, Kwok-Fai, PhD, Ellis-Behnke, Rutledge G., PhD, Wu, Wutian, PhD, Cheung, Raymond Tak-Fai, PhD
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Brain Injuries - drug therapy
Brain Injuries - pathology
Brain Injuries - physiopathology
Disease Models, Animal
In vivo
Internal Medicine
Intracerebral hemorrhage
Intracranial Hemorrhages - drug therapy
Intracranial Hemorrhages - pathology
Intracranial Hemorrhages - physiopathology
Male
Nanofibers - chemistry
Nanomaterial
Peptides - chemistry
Peptides - pharmacology
Rat
Rats
Rats, Sprague-Dawley
Recovery of Function - drug effects
Self-assembling peptide nanofiber scaffold
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Summary:Abstract There is no effective treatment for intracerebral hemorrhage (ICH). Intracerebral delivery of nanomaterials into the hemorrhagic lesion may be a new therapeutic strategy. In a rat model of ICH plus ultra-early hematoma aspiration, we found that locally delivered self-assembling peptide nanofiber scaffold (SAPNS) replaced the hematoma, reduced acute brain injury and brain cavity formation, and improved sensorimotor functional recovery. SAPNS serves as biocompatible material in the hemorrhagic brain cavity. Local delivery of this nanomaterial may facilitate the repair of ICH related brain injury and functional recovery. From the Clinical Editor In a rat model of intracranial hemorrhage, these authors demonstrate that following ultra-early hematoma aspiration, local delivery of a self-assembling peptide nanofiber scaffold replaces the hematoma, reduces brain cavity formation, and improves sensorimotor functional recovery. Similar approaches would be welcome additions to the clinical treatment of this often devastating condition.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2014.05.012