Two-dimensional longitudinal strains and torsion analysis to assess the protective effects of ischemic postconditioning on myocardial function: A speckle tracking echocardiography study in rabbits

•After reperfusion, regional strain and torsion parameters recover with I-PostC.•The correlations between SRsys, Ssys and AN/AR are more significant.•The repeatability of STE parameters is very good, especially for GSsys and Ssys.•STE quantitatively assesses LV function and the cardioprotective effe...

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Published in:Ultrasonics 2015-02, Vol.56, p.344-353
Main Authors: Liu, Y.J., Leng, X.P., Du, G.Q., Wang, X.D., Tian, J.W., Ren, M.
Format: Article
Language:English
Subjects:
Animals
Correlation
Echocardiography
Echocardiography - methods
Heart - physiopathology
Ischemic Postconditioning
Mathematical models
Myocardial ischemia
Rabbit
Rabbits
Regional
Reperfusion
Speckle tracking echocardiography
Strain
Strain rate
Tracking
Ventricular Function - physiology
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description •After reperfusion, regional strain and torsion parameters recover with I-PostC.•The correlations between SRsys, Ssys and AN/AR are more significant.•The repeatability of STE parameters is very good, especially for GSsys and Ssys.•STE quantitatively assesses LV function and the cardioprotective effects of I-PostC.•Ssys is an appropriate index to indicate myocardial dysfunction. The reperfusion injury that occurs in the early reperfusion often results in myocardial dysfunction. This study evaluated global and regional left ventricular (LV) function using speckle tracking echocardiography (STE) in a rabbit ischemia–reperfusion (I/R) model with and without ischemic postconditioning (I-PostC). The aim is to investigate the potential benefit of I-PostC for myocardial function and validate whether regional longitudinal strain is an appropriate index to indicate myocardial dysfunction. Forty rabbits were divided into an ischemia–reperfusion group (group I) and an I-PostC group (group II). After the coronary arteries were ligated, LV systolic strain and twist parameters decreased, and absolute value of strain rate of isovolumetric relaxation period (SRivr) and post-systolic strain index (PSI) increased significantly in both groups (all p
doi_str_mv 10.1016/j.ultras.2014.08.024
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The reperfusion injury that occurs in the early reperfusion often results in myocardial dysfunction. This study evaluated global and regional left ventricular (LV) function using speckle tracking echocardiography (STE) in a rabbit ischemia–reperfusion (I/R) model with and without ischemic postconditioning (I-PostC). The aim is to investigate the potential benefit of I-PostC for myocardial function and validate whether regional longitudinal strain is an appropriate index to indicate myocardial dysfunction. Forty rabbits were divided into an ischemia–reperfusion group (group I) and an I-PostC group (group II). After the coronary arteries were ligated, LV systolic strain and twist parameters decreased, and absolute value of strain rate of isovolumetric relaxation period (SRivr) and post-systolic strain index (PSI) increased significantly in both groups (all p&lt;0.05). After reperfusion, regional longitudinal systolic strain rate (SRsys), systolic strain (Ssys), LV twist and untwisting rate increased, and SRivr and PSI decreased in group II. These changes were not seen in group I. All STE parameters were correlated with area of necrosis (AN)/area at risk (AR) (all p&lt;0.05). The correlations were morerelevant between SRsys and AN/AR (r=−0.673) and between Ssys and AN/AR (r=−0.777) (both p&lt;0.001). The intra- and inter-observer repeatability of STE parameters were good with correlation coefficients (CCs) &gt;0.8 or 0.6. The sensitivities of GSRsys, GSsys, SRsys, Ssys, and LV twist to detect the myocardial infarction were 81.3%, 62.5%, 87.5%, 93.8% and 81.3%, respectively. And the specificities of those parameters were 75.0%, 81.2%, 75.0%, 87.5% and 68.7%. These results indicate that STE is useful for quantitative detection on myocardial function improvement induced by I-PostC in a rabbit I/R model. 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The reperfusion injury that occurs in the early reperfusion often results in myocardial dysfunction. This study evaluated global and regional left ventricular (LV) function using speckle tracking echocardiography (STE) in a rabbit ischemia–reperfusion (I/R) model with and without ischemic postconditioning (I-PostC). The aim is to investigate the potential benefit of I-PostC for myocardial function and validate whether regional longitudinal strain is an appropriate index to indicate myocardial dysfunction. Forty rabbits were divided into an ischemia–reperfusion group (group I) and an I-PostC group (group II). After the coronary arteries were ligated, LV systolic strain and twist parameters decreased, and absolute value of strain rate of isovolumetric relaxation period (SRivr) and post-systolic strain index (PSI) increased significantly in both groups (all p&lt;0.05). After reperfusion, regional longitudinal systolic strain rate (SRsys), systolic strain (Ssys), LV twist and untwisting rate increased, and SRivr and PSI decreased in group II. These changes were not seen in group I. All STE parameters were correlated with area of necrosis (AN)/area at risk (AR) (all p&lt;0.05). The correlations were morerelevant between SRsys and AN/AR (r=−0.673) and between Ssys and AN/AR (r=−0.777) (both p&lt;0.001). The intra- and inter-observer repeatability of STE parameters were good with correlation coefficients (CCs) &gt;0.8 or 0.6. The sensitivities of GSRsys, GSsys, SRsys, Ssys, and LV twist to detect the myocardial infarction were 81.3%, 62.5%, 87.5%, 93.8% and 81.3%, respectively. And the specificities of those parameters were 75.0%, 81.2%, 75.0%, 87.5% and 68.7%. These results indicate that STE is useful for quantitative detection on myocardial function improvement induced by I-PostC in a rabbit I/R model. 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subjects Animals
Correlation
Echocardiography
Echocardiography - methods
Heart - physiopathology
Ischemic Postconditioning
Mathematical models
Myocardial ischemia
Rabbit
Rabbits
Regional
Reperfusion
Speckle tracking echocardiography
Strain
Strain rate
Tracking
Ventricular Function - physiology
title Two-dimensional longitudinal strains and torsion analysis to assess the protective effects of ischemic postconditioning on myocardial function: A speckle tracking echocardiography study in rabbits
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