Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles

Abstract FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the...

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Bibliographic Details
Published in:Biomaterials 2013-01, Vol.34 (4), p.1128-1134
Main Authors: Chen, Cheng-Lung, Kuo, Ling-Ru, Lee, Shin-Yu, Hwu, Yeu-Kuang, Chou, Shang-Wei, Chen, Chia-Chun, Chang, Fu-Hsiung, Lin, Kung-Hsuan, Tsai, Dzung-Han, Chen, Yang-Yuan
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Biomedical materials
Cancer
Cancer therapy
Cell Line, Tumor
Dentistry
FePt
Ferrous alloys
Hyperthermia, Induced - methods
Intermetallics
Iron - therapeutic use
Iron compounds
Laser
Lasers
Low-Level Light Therapy - methods
Magnetic properties
Mammary Neoplasms, Experimental - pathology
Mammary Neoplasms, Experimental - therapy
Mice
Nanoparticle
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Photothermal therapy
Platinum - therapeutic use
Platinum compounds
Radiation Dosage
Therapy
Thermal lens
Treatment Outcome
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Summary:Abstract FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2012.10.044