Bifunctional Amine-Squaramides: Powerful Hydrogen-Bonding Organocatalysts for Asymmetric Domino/Cascade Reactions

Organocatalytic domino/cascade reactions provide a convenient method for the construction of complex molecular structures bearing multiple stereocenters in a highly stereoselective fashion. Among various organocatalysts, bifunctional squaramides have emerged as powerful hydrogen‐bonding catalysts fo...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2015-02, Vol.357 (2-3), p.253-281
Main Authors: Chauhan, Pankaj, Mahajan, Suruchi, Kaya, Uğur, Hack, Daniel, Enders, Dieter
Format: Article
Language:English
Subjects:
Arrays
Asymmetry
Bearing
bifunctional catalysts
Cascades
Catalysis
Catalysts
domino reactions
hydrogen bonding
Molecular structure
organocatalysis
squaramides
Synthesis
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Summary:Organocatalytic domino/cascade reactions provide a convenient method for the construction of complex molecular structures bearing multiple stereocenters in a highly stereoselective fashion. Among various organocatalysts, bifunctional squaramides have emerged as powerful hydrogen‐bonding catalysts for promoting a wide array of useful asymmetric organocascade sequences. Higher activity and ease of preparation make these catalysts excellent alternatives for thiourea‐based organocatalysts. This review highlights the advances in the rapidly growing field of amine‐squaramide‐catalyzed domino/cascade reactions and their mode of action.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201401003