Impacts of the feed contaminant deoxynivalenol on the intestine of monogastric animals: poultry and swine

• Published in: Journal of applied toxicology 2015-04, Vol.35 (4), p.327-337
• Main Authors: Ghareeb, Khaled, Awad, Wageha A., Böhm, Josef, Zebeli, Qendrim
• Format: Article
• Language: English
• Subjects: Activation; Animal Feed; Animals; Cereals; Contaminants; Deoxynivalenol; Feeds; Food Contamination; Foodborne Diseases - etiology; Foodborne Diseases - metabolism; Foodborne Diseases - veterinary; Gene expression; Genes; Hogs; immune function; Immunology; Intestinal Absorption - drug effects; intestinal barrier function; Intestinal Mucosa - drug effects; Intestinal Mucosa - enzymology; Intestinal Mucosa - metabolism; Intestines; Intestines - drug effects; Intestines - enzymology; Intestines - metabolism; Kinases; Malabsorption Syndromes - chemically induced; Malabsorption Syndromes - metabolism; Malabsorption Syndromes - veterinary; MAP Kinase Signaling System - drug effects; Mycotoxins - toxicity; nutrient absorption; pigs; Poultry; Poultry Diseases - chemically induced; Poultry Diseases - enzymology; Poultry Diseases - metabolism; Proteins; Signalling; Sus scrofa; Swine; Swine Diseases - chemically induced; Swine Diseases - enzymology; Swine Diseases - metabolism; Toxicology; Trichothecenes - toxicity
• ISSN: 0260-437X; 1099-1263
• DOI: 10.1002/jat.3083

Deoxynivalenol (DON) is one of the most prevalent cereal contaminants with major public health concerns owing to its high toxigenic potentials. Once ingested, DON first and foremost targets epithelial cells of the gastrointestinal tract, whose proper functioning, as the first line of defence, is of paramount importance for the host's health. Emerging evidences, summarized in this article, suggest that DON produces its toxicity primarily via activation of the mitogen‐activated protein kinases (MAPKs) signalling pathway and alteration in the expression of genes responsible for key physiological and immunological functions of the intestinal tissue of chickens and pigs. The activation of MAPKs signalling cascade results in disruption of the gut barrier function and an increase in the permeability by reducing expression of the tight junction proteins. Exposure to DON also down‐regulates the expression of multiple transporter systems in the enterocytes with subsequent impairment of the absorption of key nutrients. Other major intestinal cytotoxic effects of DON described herein are modulation of mucosal immune responses, leading to immunosupression or stimulation of local immune cells and cytokine release, and also facilitation of the persistence of intestinal pathogens in the gut. Both of the last events potentiate enteric infections and local inflammation in pigs and poultry, rendering enterocytes and the host more vulnerable to luminal toxic compounds. This review highlights the cytotoxic risks associated with the intake of even low levels of DON and also identifies gaps of knowledge that need to be addressed by future research. Copyright © 2014 John Wiley & Sons, Ltd. Deoxynivalenol is cereal contaminant, targets the intestinal epithelium with major public health concerns. Emerging evidences suggest that DON produces its toxicity primarily via activation of the mitogen‐activated protein kinases (MAPKs) signalling and alteration in the expression of genes of physiological and immunological functions. Furthermore, DON down‐regulates the expression of multiple transporters in the enterocytes and modulates mucosal immune responses. This review highlights DON impacts on the intestine and identifies gaps of knowledge that need to be addressed by future research.