Ribosome-inactivating proteins: From toxins to useful proteins

Ribosome-inactivating proteins (RIPs) either single-chain (type 1) or two-chain (type 2) are frequent in plants, often in multiple forms. They are RNA N-glycosidases, have antiviral, antifungal and insecticidal activity. Their expression in plants is increased under stressful conditions. They are in...

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Bibliographic Details
Published in:Toxicon (Oxford) 2013-06, Vol.67, p.12-16
Main Author: Stirpe, Fiorenzo
Format: Article
Language:English
Subjects:
Agriculture
Algal Proteins - therapeutic use
Algal Proteins - toxicity
Animals
antibodies
Antifungal
Antifungal Agents
Antiviral
Antiviral Agents
Bacterial Proteins - therapeutic use
Bacterial Proteins - toxicity
Carriers
Conjugates
drought
Fungal Proteins - therapeutic use
Fungal Proteins - toxicity
fungi
Humans
Immunotoxins
Immunotoxins - therapeutic use
Immunotoxins - toxicity
Insecticidal activity
insecticidal properties
Insecticides
Insects
Medicine
Pest Control, Biological
Plant Proteins - therapeutic use
Plant Proteins - toxicity
Proteins
Resistance to stress
Ribosome Inactivating Proteins - therapeutic use
Ribosome Inactivating Proteins - toxicity
Ribosome-inactivating proteins
RNA
Salinity
toxicity
Toxins
Viruses
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Summary:Ribosome-inactivating proteins (RIPs) either single-chain (type 1) or two-chain (type 2) are frequent in plants, often in multiple forms. They are RNA N-glycosidases, have antiviral, antifungal and insecticidal activity. Their expression in plants is increased under stressful conditions. They are investigated for practical applications in medicine and in agriculture. In medicine, RIPs have been linked to, or fused with, appropriate antibodies or other carriers to form “immunotoxins” or other conjugates specifically toxic to the cells target of the carrier, with the aim of eliminating malignant or other undesired cells. In agriculture, it has been observed that an enhanced expression of RIPs confers to plants an increased resistance to viruses, fungi, insects, and also to drought and salinity.
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2013.02.005