Preparation of novel hybrid gels from polyaspartamides and natural alginate or hyaluronate by click reaction

Novel polyaspartamide derivatives with pendant azide groups were prepared and used to prepare click gels. Two bis-alkyne reagents, bis-propargyl-succinate and bis-propargyl hexane urethane, were synthesized and used as the crosslinkers; these materials contain either labile esters or urethane linkag...

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Bibliographic Details
Published in:Journal of polymer research 2015-03, Vol.22 (3), p.1-12, Article 27
Main Authors: Bui, Quang Tri, Jeon, Young-Sil, Um, Soong Ho, Chung, Dong June, Kim, Ji-Heung
Format: Article
Language:English
Subjects:
Alginates
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Crosslinking
Degradation
Derivatives
Esters
Gels
Industrial Chemistry/Chemical Engineering
Jewelry
Morphology
Original Paper
Polymer Sciences
Urethanes
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Summary:Novel polyaspartamide derivatives with pendant azide groups were prepared and used to prepare click gels. Two bis-alkyne reagents, bis-propargyl-succinate and bis-propargyl hexane urethane, were synthesized and used as the crosslinkers; these materials contain either labile esters or urethane linkages, respectively. Furthermore, biocompatible hybrid click gels were prepared from azide-modified polyaspartamide and either alkynated alginate or hyaluronic acid. These hybrid gels are a promising alternative to conventional gels in various biomedical applications. The gelation behavior and outstanding swelling and deswelling properties of the gels were characterized as a function of their composition and solution pH. The morphology of the microporous gel scaffolds was observed by SEM. The hydrogel exhibited a low cytotoxicity which was evaluated by MTT assay. In addition, the preliminary hydrolytic degradation behavior of the click gels was also examined in PBS at 37 °C.
ISSN:1022-9760
1572-8935
DOI:10.1007/s10965-014-0649-3