Granulocyte colony‐stimulating factor‐producing lung cancer and acute respiratory distress syndrome

Granulocyte colony‐stimulating factor (G‐CSF)‐producing lung cancers are known to cause extreme leukocytosis. However, acute respiratory distress syndrome (ARDS) caused by G‐CSF‐producing lung cancer is extremely rare. We present a case of G‐CSF‐producing lung cancer with marked leukocytosis, which...

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Bibliographic Details
Published in:The clinical respiratory journal 2015-04, Vol.9 (2), p.250-252
Main Authors: Inokuchi, Ryota, Manabe, Haruki, Ohta, Fumihito, Nakamura, Kensuke, Nakajima, Susumu, Yahagi, Naoki
Format: Article
Language:English
Subjects:
ARDS
Carcinoma - diagnosis
Carcinoma - etiology
Fatal Outcome
Granulocyte Colony-Stimulating Factor - physiology
G‐CSF
Humans
large‐cell carcinoma
leukocytosis
Leukocytosis - diagnosis
Leukocytosis - etiology
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - etiology
Male
Middle Aged
Respiratory diseases
Respiratory distress syndrome
Respiratory Distress Syndrome, Adult - diagnosis
Respiratory Distress Syndrome, Adult - etiology
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Summary:Granulocyte colony‐stimulating factor (G‐CSF)‐producing lung cancers are known to cause extreme leukocytosis. However, acute respiratory distress syndrome (ARDS) caused by G‐CSF‐producing lung cancer is extremely rare. We present a case of G‐CSF‐producing lung cancer with marked leukocytosis, which rapidly led to severe ARDS after the patient developed pneumonia. The present case suggests that extreme leukocytosis may easily lead to ARDS, triggered by infection. Thus, G‐CSF‐producing lung cancer with marked leukocytosis should be carefully monitored before surgery and during treatment.
ISSN:1752-6981
1752-699X
DOI:10.1111/crj.12111