Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: Effect of tumor microenvironment

Highlights • Sleep apnea is characterized by intermittent hypoxia (IH), and is associated with adverse cancer outcomes. • IH-induced changes in TAMs contribute to increased tumor proliferation and invasion in mice. • Adipose tissue macrophages show differential polarization under IH, depending on th...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2015-06, Vol.361 (2), p.233-239
Main Authors: Almendros, Isaac, Gileles-Hillel, Alex, Khalyfa, Abdelnaby, Wang, Yang, Zhang, Shelley X, Carreras, Alba, Farré, Ramon, Gozal, David
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - metabolism
Adipose Tissue - pathology
Animals
Body fat
Cancer
Cell Hypoxia - physiology
Disease Models, Animal
Flow cytometry
Genotype & phenotype
Hematology, Oncology and Palliative Medicine
Hypoxia
Immune system
Inflammation
Intermittent hypoxia
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Macrophages
Macrophages - pathology
Male
Mice
Mice, Inbred C57BL
Polarization
Sleep
Sleep apnea
Sleep Apnea, Obstructive - metabolism
Sleep Apnea, Obstructive - pathology
T-Lymphocytes, Regulatory - metabolism
T-Lymphocytes, Regulatory - pathology
Tumor Microenvironment - physiology
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Sleep apnea is characterized by intermittent hypoxia (IH), and is associated with adverse cancer outcomes. • IH-induced changes in TAMs contribute to increased tumor proliferation and invasion in mice. • Adipose tissue macrophages show differential polarization under IH, depending on the presence or absence of tumor. • Increased Tregs in the ipsilateral adipose tissue to the tumor may contribute to alter polarity of macrophages toward M2 phenotype.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.03.010