Diabetes causes morphological changes in human submandibular gland: a morphometric study

Background Dataon structural alterations in human diabetic salivary glands are scanty and conflicting. The goal of this study is based on the evaluation of the morphological changes in submandibular glands of subjects with well‐controlled diabetes and without evident salivary malfunctions. Methods S...

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Published in:Journal of oral pathology & medicine 2015-04, Vol.44 (4), p.291-295
Main Authors: Lilliu, Maria Alberta, Solinas, Paola, Cossu, Margherita, Puxeddu, Roberto, Loy, Francesco, Isola, Raffaella, Quartu, Marina, Melis, Tiziana, Isola, Michela
Format: Article
Language:English
Subjects:
Acinar Cells - pathology
Acinar Cells - ultrastructure
Case-Control Studies
Dentistry
diabetes
Diabetes Mellitus, Type 2 - pathology
Humans
Lipid Droplets
Male
Microscopy, Electron, Scanning
Middle Aged
Mitochondrial Size
morphometric analysis
submandibular
Submandibular Gland - pathology
Submandibular Gland - secretion
Submandibular Gland - ultrastructure
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Summary:Background Dataon structural alterations in human diabetic salivary glands are scanty and conflicting. The goal of this study is based on the evaluation of the morphological changes in submandibular glands of subjects with well‐controlled diabetes and without evident salivary malfunctions. Methods Submandibular gland pieces from diabetic and non‐diabetic patients were fixed, dehydrated, and processed to obtain sections for light and electron microscopy. Randomly selected micrographs were statistically analyzed to reveal variations in serous acini. Results Morphometrical evaluation allowed us to reveal significant changes such as enlargement of acinar and granule size, reduction of mitochondrial size, increased density of microbuds and protrusions along luminal membranes. Conclusions The results indicate that diabetes affects submandibular gland structure even when glandular function appears unaltered and suggest that morphological changes reflect functional changes chiefly regarding the secretory activity.
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.12238