Live birth rates after combined adjuvant therapy in IVF–ICSI cycles: a matched case-control study

Abstract The effectiveness of combined co-treatment with aspirin, doxycycline, prednisolone, with or without oestradiol patches, was investigated on live birth (LBR) rates after fresh and frozen embryo transfers (FET) in IVF and intracytoplasmic sperm injection cycles. Cases ( n = 485) and controls...

Full description

Saved in:
Bibliographic Details
Published in:Reproductive biomedicine online 2015-04, Vol.30 (4), p.340-348
Main Authors: Motteram, C, Vollenhoven, B, Hope, N, Osianlis, T, Rombauts, L.J
Format: Article
Language:English
Subjects:
Adult
antibiotics
aspirin
Aspirin - therapeutic use
Birth Rate
Case-Control Studies
Combined Modality Therapy
Doxycycline - therapeutic use
Embryo Transfer - methods
Estradiol - therapeutic use
Female
Fertilization in Vitro
Humans
in-vitro fertilization
intracytoplasmic sperm injection
Male
Obstetrics and Gynecology
oestradiol
prednisolone
Prednisolone - therapeutic use
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Sperm Injections, Intracytoplasmic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The effectiveness of combined co-treatment with aspirin, doxycycline, prednisolone, with or without oestradiol patches, was investigated on live birth (LBR) rates after fresh and frozen embryo transfers (FET) in IVF and intracytoplasmic sperm injection cycles. Cases ( n = 485) and controls ( n = 485) were extensively matched in a one-to-one ratio on nine physical and clinical parameters: maternal age, body mass index, smoking status, stimulation cycle number, cumulative dose of FSH, stimulation protocol, insemination method, day of embryo transfer and number of embryos transferred. No significant differences were found in fresh cycles between cases and controls for the pregnancy outcomes analysed, but fewer surplus embryos were available for freezing in the combined adjuvant group. In FET cycles, LBR was lower in the treatment group (OR: 0.49, 95% CI 0.25 to 0.95). The lower LBR in FET cycles seemed to be clustered in patients receiving combined adjuvant treatment without luteal oestradiol (OR 0.37, 95% CI 0.17 to 0.80). No difference was found in LBR between cases and controls when stratified according to the number of previous cycles (
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2014.12.004