Medication Adherence and Attrition to Biologic Treatment in Rheumatoid Arthritis Patients

Abstract Purpose The objectives of this study were to assess medication adherence rate and attrition rate in first-time adalimumab (ADA) or etanercept (ETA) users in rheumatoid arthritis (RA) patients. This study also identified the risk factors associated with nonadherence and treatment abandonment...

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Bibliographic Details
Published in:Clinical therapeutics 2015-03, Vol.37 (3), p.660-666.e8
Main Authors: Chu, Li-Hao, MS, MPH, Kawatkar, Aniket A., PhD, Gabriel, Sherine E., MD, MSc
Format: Article
Language:English
Subjects:
Adalimumab - therapeutic use
Adolescent
Adult
Aged
anti-TNF
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy
California
Drug therapy
Electronic health records
Etanercept - therapeutic use
Ethnicity
Female
Follow-Up Studies
Humans
Internal Medicine
Logistic Models
Male
Medical Education
Medical records
Medicare
Medication Adherence
medication attrition rate
Middle Aged
Nonsteroidal anti-inflammatory drugs
Occupational therapy
Odds Ratio
Pharmacy
Physicians
Retrospective Studies
Rheumatoid arthritis
Risk factors
Substance abuse treatment
treatment abandonment
Young Adult
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Summary:Abstract Purpose The objectives of this study were to assess medication adherence rate and attrition rate in first-time adalimumab (ADA) or etanercept (ETA) users in rheumatoid arthritis (RA) patients. This study also identified the risk factors associated with nonadherence and treatment abandonment. Methods This was a retrospective study with a 2-year follow-up. A total 2151 adult RA patients (18 years of age and older) who initiated ADA or ETA treatment in the Kaiser Permanente Southern California health plan between 2002 and 2009 were identified. Among those on treatment in the first year, continuous treatment receipt was determined by having at least 1 medication refill in the second year; otherwise treatment was considered as abandoned. Medication adherence was measured through proportion of days covered (PDC) and compared between patients continuously on treatment and those abandoning treatment. Risk factors of nonadherence (PDC
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2014.10.022