Low Glutathione Peroxidase Activity Levels in Patients with Vitiligo

Background Vitiligo is an idiopathic skin disease characterized by white areas on the skin due to loss of the functional melanocytes, with possible involvement of oxidative stress. Glutathione peroxidase (GPx) is an antioxidant enzyme that protects cells against oxidative damage. Aim To examine seru...

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Bibliographic Details
Published in:Journal of cutaneous medicine and surgery 2015-03, Vol.19 (2), p.144-148
Main Authors: Zedan, Hatem, Abdel-Motaleb, Amira Ali, Kassem, Nahed Mahmoud Ali, Hafeez, Heba Ahmed Abdel, Hussein, Mahmoud Rezk Abdelwhahed
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Child
Enzyme-Linked Immunosorbent Assay
Enzymes
Female
Follow-Up Studies
Glutathione Peroxidase - blood
Humans
Male
Middle Aged
Retrospective Studies
Severity of Illness Index
Vitiligo
Vitiligo - enzymology
Young Adult
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Summary:Background Vitiligo is an idiopathic skin disease characterized by white areas on the skin due to loss of the functional melanocytes, with possible involvement of oxidative stress. Glutathione peroxidase (GPx) is an antioxidant enzyme that protects cells against oxidative damage. Aim To examine serum GPx levels in patients with vitiligo and to relate the findings to the clinical features. Patients and Methods The study group included 60 patients with vitiligo and 30 matching healthy controls. GPx activity was evaluated using enzyme-linked immunosorbent assay. Results We found a significant decrease in serum GPx activity level in the patients with vitiligo compared to the healthy controls (0.29 ± 0.14 versus 0.47 ± 0.13, p < .001). The levels were significantly low in skin phenotypes III and IV (p < .001). Higher levels were also observed with increasing age (≥ 14 years), prolonged disease duration (≥ 3 years), and generalized and extensive vitiligo (
ISSN:1203-4754
1615-7109
DOI:10.2310/7750.2014.14076