Liraglutide pharmacokinetics and dose-exposure response in Asian subjects with Type 2 diabetes from China, India and South Korea

Highlights • Liraglutide exposure appeared to be dose-proportional in Asian subjects. • Body weight was found to be the only relevant predictor for exposure of liraglutide. • Exposure-response relationships were similar in Asians and in a global population.

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Bibliographic Details
Published in:Diabetes research and clinical practice 2015-04, Vol.108 (1), p.113-119
Main Authors: Ingwersen, S.H, Petri, K.C, Tandon, N, Yoon, K.-H, Chen, L, Vora, J, Yang, W
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group
Blood Glucose - analysis
China - epidemiology
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - metabolism
Double-Blind Method
Endocrinology & Metabolism
Exposure-response
Female
Glycated Hemoglobin A - analysis
Humans
Hypoglycemic Agents - pharmacokinetics
India - epidemiology
Liraglutide
Liraglutide - pharmacokinetics
Male
Middle Aged
Population pharmacokinetics
Republic of Korea - epidemiology
Treatment Outcome
Type 2 diabetes
Young Adult
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Description
Summary:Highlights • Liraglutide exposure appeared to be dose-proportional in Asian subjects. • Body weight was found to be the only relevant predictor for exposure of liraglutide. • Exposure-response relationships were similar in Asians and in a global population.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2015.01.001