Cross-protection of a new type 2 porcine reproductive and respiratory syndrome virus (PRRSV) modified live vaccine (Fostera PRRS) against heterologous type 1 PRRSV challenge in growing pigs

•The new type 2 PRRSV vaccine cross-protects pigs against type 1 PRRSV challenge.•The new type 2 PRRSV vaccine reduces the levels of type 1 PRRSV viremia.•The new type 2 PRRSV vaccine reduces the type 1 PRRSV-induced lung lesions. The objective of the present study was to determine the cross-protect...

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Bibliographic Details
Published in:Veterinary microbiology 2015-05, Vol.177 (1-2), p.87-94
Main Authors: Park, Changhoon, Choi, Kyuhyung, Jeong, Jiwoon, Chae, Chanhee
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - immunology
Cross Protection - immunology
Cross-protection
Genotype
Interferon-gamma - immunology
Interleukin-10 - immunology
Porcine Reproductive and Respiratory Syndrome - immunology
Porcine Reproductive and Respiratory Syndrome - prevention & control
Porcine reproductive and respiratory syndrome virus
Porcine respiratory and reproductive syndrome virus - immunology
Sus scrofa
Swine
Vaccination - veterinary
Vaccine
Vaccines, Attenuated - immunology
Viral Vaccines - immunology
Viremia - immunology
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Summary:•The new type 2 PRRSV vaccine cross-protects pigs against type 1 PRRSV challenge.•The new type 2 PRRSV vaccine reduces the levels of type 1 PRRSV viremia.•The new type 2 PRRSV vaccine reduces the type 1 PRRSV-induced lung lesions. The objective of the present study was to determine the cross-protection of a new type 2 porcine reproductive and respiratory syndrome virus (PRRSV) modified live vaccine against heterologous type 1 PRRSV challenge in growing pigs. The mean rectal temperature and respiratory score was significantly (P
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2015.02.020