Early diagnosis of testicular torsion in rats by measuring plasma d -dimer levels: comparative study with epididymitis

Abstract Purpose To evaluate the differential diagnosis of testicular torsion and acute epididymo-orchitis by measuring the acute increase in plasma d -dimer levels in an experimental rat model. Methods Thirty male Wistar rats were randomly divided into 5 groups, 1 – sham operated group (acute term;...

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Published in:Journal of pediatric surgery 2015-04, Vol.50 (4), p.651-654
Main Authors: Yilmaz, Engin, Hizli, Fatih, Afşarlar, Çağatay Evrim, Demirtaş, Canan, Apaydin, Sema, Karaman, İbrahim, Karaman, Ayşe
Format: Article
Language:English
Subjects:
Animals
Biomarkers - blood
d-dimer
Diagnosis, Differential
Disease Models, Animal
Early Diagnosis
epididymitis
Epididymitis - blood
Epididymitis - diagnosis
Fibrin Fibrinogen Degradation Products - metabolism
Male
Pediatrics
rat model
Rats
Rats, Wistar
Spermatic Cord Torsion - blood
Spermatic Cord Torsion - diagnosis
Surgery
Testicular torsion
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Summary:Abstract Purpose To evaluate the differential diagnosis of testicular torsion and acute epididymo-orchitis by measuring the acute increase in plasma d -dimer levels in an experimental rat model. Methods Thirty male Wistar rats were randomly divided into 5 groups, 1 – sham operated group (acute term; 4 hours), 2 – early torsion group (acute term; 4 hours), 3 – late torsion group (long-term; 72 hours), 4 – control of epididymitis group (vehicle injected; 0.1 ml physiologic saline injected into the left ductus deferens) (long term; 72 hours), 5 – epididymitis group (0.1 ml Escherichia coli injected into the left ductus deferens), (n = 6 for each group). Results Serum d -dimer levels were significantly higher compared with the sham operated group with early torsion (p = 0.002). This elevation remained mildly in the late torsion group compared with the control group (p < 0.001), but there was no difference between 4 and 72 hours of the testis torsions (p = 0.794). On the other hand, d -dimer levels were significantly higher in the torsion groups compared to the epididymitis group (p = 0.042). Conclusions The present study demonstrated that testicular damage that occurs following testicular torsion shows a higher increase in d -dimer levels than epididymitis, suggesting that d -dimer level can be used as a diagnostic marker of testicular torsion.
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2014.05.018