Epidermal nevi with aberrant epidermal structure in keratinocytes and melanocytes

Epidermal nevi are congenital cutaneous hamartomas caused by embryonic somatic mutations. Ultrastructural features of adult epidermal nevi have rarely been investigated. Herein, we report a case involving a Japanese adult who had epidermal nevi with right congenital blindness and a right accessory n...

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Bibliographic Details
Published in:Journal of dermatology 2015-04, Vol.42 (4), p.408-410
Main Authors: Oiso, Naoki, Sugawara, Koji, Yonamine, Ayano, Tsuruta, Daisuke, Kawada, Akira
Format: Article
Language:English
Subjects:
Adult
cutaneous hamartoma
electron microscopy
epidermal nevus
Female
Hamartoma - pathology
Humans
keratinocytes
Keratinocytes - pathology
melanocytes
Melanocytes - pathology
Nevus - pathology
Skin Diseases - pathology
Skin Neoplasms - pathology
Studies
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Summary:Epidermal nevi are congenital cutaneous hamartomas caused by embryonic somatic mutations. Ultrastructural features of adult epidermal nevi have rarely been investigated. Herein, we report a case involving a Japanese adult who had epidermal nevi with right congenital blindness and a right accessory nipple. The histopathologic and ultrastructural studies showed divergent abnormal epidermal structures in both melanocytes and keratinocytes. Our case indicates the need to further investigate histopathologic, ultrastructural, and genetic associations in adult epidermal nevi.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.12787