Involvement of α- and β-catenins and E-cadherin in the development of mammary phyllodes tumours

Tsang J Y S, Mendoza P, Lam C C F, Yu A M C, Putti T C, Karim R Z, Scolyer R A, Lee C S, Tan P H & Tse G M 
(2012) Histopathology 61, 667–674 Involvement of α‐ and β‐catenins and E‐cadherin in the development of mammary phyllodes tumours Aims:  Phyllodes tumours (PT) are rare but clinically impo...

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Published in:Histopathology 2012-10, Vol.61 (4), p.667-674
Main Authors: Tsang, Julia Y S, Mendoza, Paulo, Lam, Christopher C F, Yu, Alex M C, Putti, Thomas C, Karim, Rooshdiya Z, Scolyer, Richard A, Lee, Cheok Soon, Tan, Puay Hoon, Tse, Gary M
Format: Article
Language:English
Subjects:
alpha Catenin - biosynthesis
beta Catenin - biosynthesis
Biological and medical sciences
Biomarkers, Tumor - metabolism
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cadherins - biosynthesis
E-cadherin
Female
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Neoplasm Recurrence, Local - metabolism
Neoplasm Recurrence, Local - pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Phyllodes Tumor - metabolism
Phyllodes Tumor - pathology
phyllodes tumour
Prognosis
α-catenin
β-catenin
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Summary:Tsang J Y S, Mendoza P, Lam C C F, Yu A M C, Putti T C, Karim R Z, Scolyer R A, Lee C S, Tan P H & Tse G M 
(2012) Histopathology 61, 667–674 Involvement of α‐ and β‐catenins and E‐cadherin in the development of mammary phyllodes tumours Aims:  Phyllodes tumours (PT) are rare but clinically important fibroepithelial tumours of the breast. β‐Catenin, a key component in Wnt signalling, has been shown to be important in the development of PT. It also functions as a component of the cadherin complex, which may therefore be implicated in PT pathogenesis. By assessing stromal α‐catenin, β‐catenin and E‐cadherin expression in 158 PT cases using immunohistochemistry and examining associations with clinicopathological features, we aimed to determine the role of these proteins in PT pathogenesis. Methods and results:  Cytoplasmic β‐catenin correlated with α‐catenin expression. A significantly higher expression of both markers was observed in borderline than in benign PT (P = 0.003 and
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.2012.04271.x