Bioinspired core-crosslinked micelles from thymine-functionalized amphiphilic block copolymers: Hydrogen bonding and photo-crosslinking study

Bioinspired core‐bound polymeric micelles, based on hydrogen bonding and photo‐crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)‐b‐poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2‐tetramethylpiperidin‐1‐oxyl‐mediated living ra...

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Published in:Journal of polymer science. Part A, Polymer chemistry Polymer chemistry, 2011-10, Vol.49 (19), p.4121-4128
Main Authors: Kaur, Gagan, Chang, Shery L. Y., Bell, Toby D. M., Hearn, Milton T. W., Saito, Kei
Format: Article
Language:English
Subjects:
Applied sciences
biomimetic
block copolymer
Block copolymers
Chemical bonds
Chlorides
Control stability
core-shell polymers
Crosslinking
Ethylene glycol
Exact sciences and technology
Hydrogen bonding
Micelles
Organic polymers
Physicochemistry of polymers
Polymers with particular properties
Preparation, kinetics, thermodynamics, mechanism and catalysts
Radicals
Stability
Thymine
Ultraviolet radiation
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Summary:Bioinspired core‐bound polymeric micelles, based on hydrogen bonding and photo‐crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)‐b‐poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2‐tetramethylpiperidin‐1‐oxyl‐mediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core‐crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011 Bioinspired core‐bound polymeric micelles, based on hydrogen bonding and photo‐crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)‐b‐poly(vinylbenzyltriethylammonium chloride). Micelle characterization, and critical micelle concentration measurements, and thermostability examination demonstrated that the hydrogen bonding and photo‐crosslinking of the attached thymine units stabilizes the micelles.
ISSN:0887-624X
1099-0518
1099-0518
DOI:10.1002/pola.24853