Thermodynamics of the Amphiphilic Drug, Amitriptyline Hydrochloride-Surfactant/Polymer Systems at the Cloud Point

Herein, we report the energetics of clouding in amphiphilic drug, amitriptyline hydrochloride (AMT-a tricyclic antidepressant drug), in the presense of surfactants and polymers. Surfactants/polymers are extensively used in drug delivery as drug carriers. The cloud point (CP) of an amphiphile can be...

Full description

Saved in:
Bibliographic Details
Published in:Journal of dispersion science and technology 2010-12, Vol.31 (12), p.1721-1726
Main Authors: Alam, Md. Sayem, Kabir-ud-Din, Mandal, Asit Baran
Format: Article
Language:English
Subjects:
Amitriptyline
amphiphilic drug
Antidepressants
Chemistry
cloud point
Clouds
Colloidal state and disperse state
Dispersions
Drugs
Exact sciences and technology
General and physical chemistry
Gibbs free energy change
Polymers
Solubility
Solubilization
Surfactants
Thermodynamics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Herein, we report the energetics of clouding in amphiphilic drug, amitriptyline hydrochloride (AMT-a tricyclic antidepressant drug), in the presense of surfactants and polymers. Surfactants/polymers are extensively used in drug delivery as drug carriers. The cloud point (CP) of an amphiphile can be considered as the limit of its solubility. The clouding components release their solvated water and separate out from the solution. Hence, the standard Gibbs free energy change of solubilization is evaluated from the relation . For all the additives, is found to be positive. However, and values are negative as well as positive depending upon the type and nature of the additive and the results are discussed on the basis of these factors.
ISSN:0193-2691
1532-2351
DOI:10.1080/01932690903542784