Effect of γ-dose rate and total dose interrelation on the polymeric hydrogel: A novel injectable male contraceptive

Functional necessity to use a particular range of dose rate and total dose of γ-initiated polymerization to manufacture a novel polymeric hydrogel RISUG ® (reversible inhibition of sperm under guidance) made of styrene maleic anhydride (SMA) dissolved in dimethyl sulphoxide (DMSO), for its broad bio...

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Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2010-05, Vol.79 (5), p.663-671
Main Authors: Jha, Pradeep K., Jha, Rakhi, Gupta, B.L., Guha, Sujoy K.
Format: Article
Language:English
Subjects:
Contraceptives
Dissolution
Dosage
FESEM
Field emission
FTIR
Hydrogels
MALDI–TOF
Polymeric hydrogel
Polymerization
RISUG
Scanning electron microscopy
Styrenes
Total dose
γ-dose rate
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Summary:Functional necessity to use a particular range of dose rate and total dose of γ-initiated polymerization to manufacture a novel polymeric hydrogel RISUG ® (reversible inhibition of sperm under guidance) made of styrene maleic anhydride (SMA) dissolved in dimethyl sulphoxide (DMSO), for its broad biomedical application explores new dimension of research. The present work involves 16 irradiated samples. They were tested by fourier transform infrared spectroscopy, matrix assisted laser desorption/ionization–TOF, field emission scanning electron microscopy, high resolution transmission electron microscopy, etc. to see the interrelation effect of gamma dose rates (8.25, 17.29, 20.01 and 25.00 Gy/min) and four sets of doses (1.8, 2.0, 2.2 and 2.4 kGy) on the molecular weight, molecular weight distribution and porosity analysis of the biopolymeric drug RISUG ®. The results of randomized experiment indicated that a range of 18–24 Gy/min γ-dose rate and 2.0–2.4 kGy γ-total doses is suitable for the desirable in vivo performance of the contraceptive copolymer.
ISSN:0969-806X
1879-0895
DOI:10.1016/j.radphyschem.2009.11.010