Design of molecularly imprinted polymer grafts with embedded gold nanoparticles through the interfacial chemistry of aryl diazonium salts

A novel strategy is described for the preparation of highly sensitive molecularly imprinted (MIPs) sensors for dopamine. It combines mercaptobenzene diazonium salt as a coupling agent for immobilizing gold nanoparticles to gold electrodes and benzoyl benzene diazonium salt as photoinitiator of radic...

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Bibliographic Details
Published in:Polymer (Guilford) 2011-09, Vol.52 (20), p.4463-4470
Main Authors: Gam-Derouich, Sarra, Mahouche-Chergui, Samia, Truong, Stephanie, Ben Hassen-Chehimi, Dalila, Chehimi, Mohamed M.
Format: Article
Language:English
Subjects:
adhesion
Applied sciences
Aromatic compounds
Aryl diazonium salts
benzene
Coupling agents
detection limit
Dopamine
Electrodes
ethylene glycol
Exact sciences and technology
Gold
Gold nanoparticles
hydrogen
molecular imprinting
Molecularly imprinted polymer grafts
Nanoparticles
Nanostructure
Physicochemistry of polymers
Polymerization
polymers
Polymers and radiations
salts
Strategy
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Summary:A novel strategy is described for the preparation of highly sensitive molecularly imprinted (MIPs) sensors for dopamine. It combines mercaptobenzene diazonium salt as a coupling agent for immobilizing gold nanoparticles to gold electrodes and benzoyl benzene diazonium salt as photoinitiator of radical polymerization at the said gold nanoparticle-decorated gold electrodes. The MIP films were prepared by surface-initiated photopolymerization (SIPP) of methacrylic acid (MAA) as functional monomer (F) for dopamine (DA) the template molecule (T), and ethylene glycol dimethacrylate (EGDMA), the crosslinker (C). Dimethylaniline was employed as a hydrogen donor. The specificity and selectivity were demonstrated by square wave voltammetry (SWV). The detection limit was 0.35 nmol L-1 (0.054 ng mL−1). The sensor layers are stable and adherent to the surface through aryl layers. The originality and advantage of the process lie in the use of aryl diazonium salt as coupling agents for anchroring nanoparticles and MIP layers to the electrode surface in a simple and efficient way which ensures high sensing performance together with good surface-MIP adhesion. The same strategy can be extended to a broad range of templates. [Display omitted]
ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2011.08.007