A Novel Method for the Conversion of Carboxylic Acids to N,N -dimethylamides Using N,N -dimethylacetamide as a Dimethylamine Source

A simple, cost effective and environmentally benign method is reported for the preparation of N,N-dimethylamides from carboxylic acids. The versatility of the method is determined by synthesising a large number of N,N-dimethyl-amide derivatives. Carboxylic acids are heated at 160–165 °C in N,N-dimet...

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Bibliographic Details
Published in:Journal of chemical research 2013-03, Vol.37 (3), p.155-159
Main Authors: Aavula, Sanjeev Kumar, Chikkulapally, Anil, Hanumanthappa, N, Jyothi, Indira, Kumar, Vinod C H, Manjunatha, Sulur G, Sythana, Suresh Kumar
Format: Article
Language:English
Subjects:
Carboxylic acids
Conversion
Derivatives
Solvents
Versatility
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Summary:A simple, cost effective and environmentally benign method is reported for the preparation of N,N-dimethylamides from carboxylic acids. The versatility of the method is determined by synthesising a large number of N,N-dimethyl-amide derivatives. Carboxylic acids are heated at 160–165 °C in N,N-dimethylacetamide solvent in the presence of 1,1′-carbonyldiimidazole to afford the corresponding N,N-dimethylamides in good to excellent yields.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751913X13602686612047