Homocysteine and oxidative stress

Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (ischemic disease, such as stroke and myocardial infarction, and arterial and venous thrombotic events) in the general population. We can assume that the association is causal, based on the example of homocystinuria, and o...

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Bibliographic Details
Published in:Amino acids 2003-12, Vol.25 (3-4), p.409-417
Main Authors: Perna, A F, Ingrosso, D, De Santo, N G
Format: Article
Language:English
Subjects:
Acylation
Amino acids
Animals
Cardiovascular disease
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Epidemiology
Heart attacks
Homocysteine
Homocysteine - metabolism
Homocystinuria - complications
Humans
Hyperhomocysteinemia - complications
Hyperhomocysteinemia - metabolism
Lipoproteins, LDL - metabolism
Medical research
Models, Biological
Myocardial infarction
Oxidation
Oxidative Stress
Risk
Risk Factors
Strokes
Superoxide Dismutase - metabolism
Toxicology
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Summary:Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (ischemic disease, such as stroke and myocardial infarction, and arterial and venous thrombotic events) in the general population. We can assume that the association is causal, based on the example of homocystinuria, and on the evidence put forward by several basic science and epidemiological studies; however, the results of large intervention trials, which will grant further support to this hypothesis, are not yet available. In addition, the mechanisms underlying this relationship, and also explaining the several toxic effects of homocysteine, related or not to cardiovascular disease, are unclear. Oxidation is one of the most favored postulated mechanisms; others are nitrosylation, acylation, and hypomethylation. Regarding the relative importance of these mechanisms, each of these hold pros and cons, and these are weighed in order to propose a balance of evidence.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-003-0026-8