Gas-forming poly(ethylene glycol)-b-poly(L-lactic acid) micelles

In this study, a novel drug‐carrying micelle composed of methoxy poly(ethylene glycol) (mPEG)‐b‐poly(L‐lactic acid) (PLLA) with gas‐forming carbonate linkage was fabricated. Here, the gas‐forming carbonate linkage was formed by the chemical coupling of the terminal hydroxyl group of the PLLA block a...

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Bibliographic Details
Published in:Polymers for advanced technologies 2013-06, Vol.24 (6), p.551-556
Main Authors: Lee, Jung Ok, Kim, Dongin, Kwag, Dong Sup, Lee, Ung Yeol, Oh, Kyung Taek, Youn, Yu Seok, Oh, Young Taik, Park, Jin Woo, Lee, Eun Seong
Format: Article
Language:English
Subjects:
anticancer drug delivery
Applied sciences
Biological and medical sciences
Blocking
Carbonates
drug release kinetics
Drugs
Exact sciences and technology
gas-forming micelle
General pharmacology
Hydroxyl groups
Linkages
Medical sciences
Micelles
Nanostructure
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
poly(ethylene glycol)-b-poly(L-lactic acid)
Polylactic acid
Properties and characterization
Reproduction
Solution and gel properties
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Summary:In this study, a novel drug‐carrying micelle composed of methoxy poly(ethylene glycol) (mPEG)‐b‐poly(L‐lactic acid) (PLLA) with gas‐forming carbonate linkage was fabricated. Here, the gas‐forming carbonate linkage was formed by the chemical coupling of the terminal hydroxyl group of the PLLA block and benzyl chloroformate (BC). mPEG‐b‐PLLA‐BC was self‐organized in aqueous solution: the PEG block on the hydrophilic outer shell and the PLLA‐BC block in the hydrophoboic innor core. The cleavage of carbonate linkage by hydrolysis and formation of carbon dioxide nanobubbles in the micellar core enabled an accelerated release of the encapsulated anticancer drug (doxorubicin: DOX) from the mPEG‐b‐PLLA‐BC micelles. The amount of drug (DOX) released from the mPEG‐b‐PLLA‐BC micelle was higher than that from the conventional mPEG‐b‐PLLA micelle, which allowed for increased in vitro toxicity against KB tumor cells. Copyright © 2013 John Wiley & Sons, Ltd.
ISSN:1042-7147
1099-1581
DOI:10.1002/pat.3116