Superparamagnetic Nanostructures for Off-Resonance Magnetic Resonance Spectroscopic Imaging

This study proposes a new method to generate positive contrast in magnetic resonance imaging (MRI) using superparamagnetic contrast agents. Superparamagnetic nanostructures consisting of octahedron manganese ferrite nanoparticles embedded in spherical nanogels are fabricated using a bottom‐up approa...

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Bibliographic Details
Published in:Advanced functional materials 2013-01, Vol.23 (4), p.496-505
Main Authors: Choo, Eugene Shi Guang, Peng, Erwin, Rajendran, Reshmi, Chandrasekharan, Prashant, Yang, Chang-Tong, Ding, Jun, Chuang, Kai-Hsiang, Xue, Junmin
Format: Article
Language:English
Subjects:
biomedical applications
composite materials
Contrast agents
Imaging
magnetic nanoparticles
Magnetic resonance imaging
Nanocomposites
Nanomaterials
Nanoparticles
Nanostructure
Spectroscopy
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Summary:This study proposes a new method to generate positive contrast in magnetic resonance imaging (MRI) using superparamagnetic contrast agents. Superparamagnetic nanostructures consisting of octahedron manganese ferrite nanoparticles embedded in spherical nanogels are fabricated using a bottom‐up approach. The composite nanoparticles are strongly magnetized in an external magnetic field and produce a unique NMR frequency shift in water protons, which can be demonstrated in MR spectroscopy and imaging to be different from the bulk pool. Moreover, the particles exhibit excellent colloidal stability in aqueous media and good cell biocompatibility. Hence, these particles are potentially useful as biomarkers by taking advantage of the positive contrast effects produced in MRI. A new method is proposed that uses superparamagnetic contrast agents to generate positive contrast in magnetic resonance imaging (MRI). The nanostructure consists of octahedral manganese ferrite nanoparticles embedded in spherical nanogels. The nanocomposites are strongly magnetized in an external magnetic field and produce a unique NMR frequency shift in water protons. This structure shows potential for use in MR spectroscopic imaging.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201200275