Palladium-Catalyzed Asymmetric 1,4-Addition of Diarylphosphines to Nitroalkenes for the Synthesis of Chiral P,N-Compounds

A highly stereoselective asymmetric 1,4‐addition of diarylphosphines to nitroalkenes catalyzed by a bis(phosphine) pincer‐palladium complex has been developed for the synthesis of chiral P,N compounds with good to excellent enantioselectivities (up to 94% ee) under mild conditions.

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2012-11, Vol.354 (16), p.3122-3126
Main Authors: Feng, Jian-Jun, Huang, Miao, Lin, Zi-Qi, Duan, Wei-Liang
Format: Article
Language:English
Subjects:
1,4‐addition
4-addition
asymmetric hydrophosphination
Asymmetry
Catalysis
Catalysts: preparations and properties
Chemistry
diarylphosphines
Exact sciences and technology
General and physical chemistry
nitroalkenes
pincer palladium catalysts
Synthesis
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Description
Summary:A highly stereoselective asymmetric 1,4‐addition of diarylphosphines to nitroalkenes catalyzed by a bis(phosphine) pincer‐palladium complex has been developed for the synthesis of chiral P,N compounds with good to excellent enantioselectivities (up to 94% ee) under mild conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201200133