Semiconducting to metallic-like boron doping of nanocrystalline diamond films and its effect on osteoblastic cells

The impact of boron doping level of nanocrystalline diamond (NCD) films on the character of cell growth (i.e., adhesion, proliferation and differentiation) is presented. Intrinsic and boron-doped NCD films were grown on Si/SiO 2 substrates by microwave plasma CVD process. The boron-doped samples wer...

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Bibliographic Details
Published in:Diamond and related materials 2010-02, Vol.19 (2), p.190-195
Main Authors: Kromka, Alexander, Grausova, Lubica, Bacakova, Lucie, Vacik, Jiri, Rezek, Bohuslav, Vanecek, Milan, Williams, Oliver A., Haenen, Ken
Format: Article
Language:English
Subjects:
Adhesion
Atomic force microscopy
Biocompatibility
Biomedical materials
Boron
Boron doping
Chemical vapor deposition (including plasma-enhanced cvd, mocvd, etc.)
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Doping
Exact sciences and technology
Fullerenes and related materials
diamonds, graphite
Materials science
Mechanical and acoustical properties
Methane
Methods of deposition of films and coatings
film growth and epitaxy
Nanocrystalline diamond
Nanocrystals
Physical properties of thin films, nonelectronic
Physics
Silicon substrates
Specific materials
Surfaces and interfaces
thin films and whiskers (structure and nonelectronic properties)
Theory and models of film growth
Tissue engineering
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Summary:The impact of boron doping level of nanocrystalline diamond (NCD) films on the character of cell growth (i.e., adhesion, proliferation and differentiation) is presented. Intrinsic and boron-doped NCD films were grown on Si/SiO 2 substrates by microwave plasma CVD process. The boron-doped samples were grown by adding trimethylboron (TMB) to the gas mixture of methane and hydrogen. Highly resistive (0 ppm), semiconducting (133 or 1000 ppm), and metallic-like (6700 ppm) NCD films were tested as the artificial substrates for the cultivation of osteoblast-like MG 63 cells. The conductivity and surface charge increased monotonically with the increasing boron content. All NCD substrates showed good biocompatibility and stimulated the adhesion and growth of MG 63 cells. Higher osteocalcin concentration (by more than 30%) for the cells growing on 1000 and 6700 ppm boron-doped NCD films was found which indicates an enhancement in the cell growth biochemistry.
ISSN:0925-9635
1879-0062
DOI:10.1016/j.diamond.2009.10.003