Microreactors and CFD as Tools for Biocatalysis Reactor Design: A case study

Microreactors have been used for acquiring process data while consuming significantly lower amounts of expensive reagents. In this article, the combination of microreactor technology and computational fluid dynamics (CFD) is shown to contribute significantly towards understanding the diffusional pro...

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Bibliographic Details
Published in:Chemical engineering & technology 2013-06, Vol.36 (6), p.1017-1026
Main Authors: Bodla, V. K., Seerup, R., Krühne, U., Woodley, J. M., Gernaey, K. V.
Format: Article
Language:English
Subjects:
Biocatalysis
CFD
Chemical engineering
Computational fluid dynamics
Diffusion
Gain
Mathematical models
Microreactors
Reactor design
Reactors
Screening
Screening tool
Transaminase
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Summary:Microreactors have been used for acquiring process data while consuming significantly lower amounts of expensive reagents. In this article, the combination of microreactor technology and computational fluid dynamics (CFD) is shown to contribute significantly towards understanding the diffusional properties of the substrate and the product of a biocatalytic reaction. Such knowledge is then applied to design reactor configurations. It has been demonstrated that this kind of knowledge is crucial for the choice and design of reactors. In the discussion, it is highlighted how microreactor‐based platforms with similar dimensions to the ones tested here can be used as a screening tool for screening biocatalyst and process alternatives. The combination of microreactor technology and CFD is used to gain process understanding of the diffusional properties of the substrate and product of a biocatalytic reaction. Such knowledge is then applied to design reactor configurations. It has been demonstrated that this kind of knowledge is crucial for the choice and design of reactors.
ISSN:0930-7516
1521-4125
DOI:10.1002/ceat.201200667