Permeability and blood compatibility of nanoporous parylene film-coated polyethersulfone membrane under long-term blood diffusion

ABSTRACT Nanoporous polyethersulfone (PES) membranes are widely used in dialysis systems due to their permeability and diffusion characteristics. However, PES membranes lack blood compatibility, which influences their permeability performance when employed in blood contact devices. Parylene film was...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied polymer science 2014-03, Vol.131 (6), p.np-n/a
Main Authors: Setia Prihandana, Gunawan, Ito, Hikaru, Sanada, Ippei, Nishinaka, Yuya, Kanno, Yoshihiko, Miki, Norihisa
Format: Article
Language:English
Subjects:
Applied sciences
biocompatibility
Biological and medical sciences
biomedical applications
Blood
coatings
Diffusion
Exact sciences and technology
Exchange resins and membranes
Forms of application and semi-finished materials
Materials science
Medical sciences
Membranes
Nanocomposites
Nanomaterials
Nanostructure
Permeability
Platelets
Polymer industry, paints, wood
Polymers
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology of polymers
Technology. Biomaterials. Equipments
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Nanoporous polyethersulfone (PES) membranes are widely used in dialysis systems due to their permeability and diffusion characteristics. However, PES membranes lack blood compatibility, which influences their permeability performance when employed in blood contact devices. Parylene film was deposited on a PES membrane surface and the membrane permeability and blood compatibility were investigated by long‐term blood diffusion testing. After 28 days of testing, 90% of a bare PES membrane was covered with platelets, while the parylene film coated PES membrane had improved biocompatibility with a platelet coverage of only 20–30%. The permeability of the bare PES membrane significantly declined during the first 7 days of the blood diffusion and became stable after 8 days. In contrast, the permeability of the parylene film coated PES membrane exhibited more consistent performance during the entire test. Thus, parylene film coating on PES membrane has potential for application in hemodialysis systems. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2014, 131, 40024.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.40024