Carbon Nanodots Featuring Efficient FRET for Real-Time Monitoring of Drug Delivery and Two-Photon Imaging

A FRET‐based carbon nanodot (CDot) drug delivery platform has been developed. These CDots offer excellent biocompatibility, stable fluorescence, and efficient FRET between CDots and the attached fluorescent drug molecules, such as doxorubicin, enabling enhanced drug delivery, convenient cell imaging...

Full description

Saved in:
Bibliographic Details
Published in:Advanced materials (Weinheim) 2013-12, Vol.25 (45), p.6569-6574
Main Authors: Tang, Jing, Kong, Biao, Wu, Hao, Xu, Ming, Wang, Yongcheng, Wang, Yanli, Zhao, Dongyuan, Zheng, Gengfeng
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - toxicity
Carbon - chemistry
carbon nanodots
Cell Survival - drug effects
cytotoxicity
Doxorubicin - chemistry
Doxorubicin - toxicity
Drug Carriers - chemistry
drug delivery
Drug delivery systems
Drugs
Fluorescence Resonance Energy Transfer
FRET
Fretting
HEK293 Cells
HeLa Cells
Humans
Hydrogen-Ion Concentration
Imaging
Microscopy, Confocal
Monitoring
Nanocomposites
Nanomaterials
Nanoparticles - chemistry
Nanostructure
Photons
two-photon imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A FRET‐based carbon nanodot (CDot) drug delivery platform has been developed. These CDots offer excellent biocompatibility, stable fluorescence, and efficient FRET between CDots and the attached fluorescent drug molecules, such as doxorubicin, enabling enhanced drug delivery, convenient cell imaging, and real‐time monitoring of drug release. Moreover, the FRET‐based two‐photon imaging and drug tracking in deep tissues are also demonstrated.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201303124