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Carbon Nanodots Featuring Efficient FRET for Real-Time Monitoring of Drug Delivery and Two-Photon Imaging

A FRET‐based carbon nanodot (CDot) drug delivery platform has been developed. These CDots offer excellent biocompatibility, stable fluorescence, and efficient FRET between CDots and the attached fluorescent drug molecules, such as doxorubicin, enabling enhanced drug delivery, convenient cell imaging...

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Published in:	Advanced materials (Weinheim) 2013-12, Vol.25 (45), p.6569-6574
Main Authors:	Tang, Jing, Kong, Biao, Wu, Hao, Xu, Ming, Wang, Yongcheng, Wang, Yanli, Zhao, Dongyuan, Zheng, Gengfeng
Format:	Article
Language:	English
Subjects:	Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - toxicity Carbon - chemistry carbon nanodots Cell Survival - drug effects cytotoxicity Doxorubicin - chemistry Doxorubicin - toxicity Drug Carriers - chemistry drug delivery Drug delivery systems Drugs Fluorescence Resonance Energy Transfer FRET Fretting HEK293 Cells HeLa Cells Humans Hydrogen-Ion Concentration Imaging Microscopy, Confocal Monitoring Nanocomposites Nanomaterials Nanoparticles - chemistry Nanostructure Photons two-photon imaging
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cited_by	cdi_FETCH-LOGICAL-c4824-44639b18dcc00e1a6d626ca8e3b95b0d934a52734e98e7403813c203b4cac9613
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creator	Tang, Jing Kong, Biao Wu, Hao Xu, Ming Wang, Yongcheng Wang, Yanli Zhao, Dongyuan Zheng, Gengfeng
description	A FRET‐based carbon nanodot (CDot) drug delivery platform has been developed. These CDots offer excellent biocompatibility, stable fluorescence, and efficient FRET between CDots and the attached fluorescent drug molecules, such as doxorubicin, enabling enhanced drug delivery, convenient cell imaging, and real‐time monitoring of drug release. Moreover, the FRET‐based two‐photon imaging and drug tracking in deep tissues are also demonstrated.
doi_str_mv	10.1002/adma.201303124
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subjects	Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - toxicity Carbon - chemistry carbon nanodots Cell Survival - drug effects cytotoxicity Doxorubicin - chemistry Doxorubicin - toxicity Drug Carriers - chemistry drug delivery Drug delivery systems Drugs Fluorescence Resonance Energy Transfer FRET Fretting HEK293 Cells HeLa Cells Humans Hydrogen-Ion Concentration Imaging Microscopy, Confocal Monitoring Nanocomposites Nanomaterials Nanoparticles - chemistry Nanostructure Photons two-photon imaging
title	Carbon Nanodots Featuring Efficient FRET for Real-Time Monitoring of Drug Delivery and Two-Photon Imaging
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