Autologous bone marrow derived mononuclear cells combined with β-tricalcium phosphate and absorbable atelocollagen for a treatment of aneurysmal bone cyst of the humerus in child

Aneurysmal bone cyst is a benign, locally destructive lesion of bone. Based on progressive cortical thinning pathological fractures are common, and are often the presenting feature. Despite the long experience of orthopaedists, radiologists and pathologists with aneurysmal bone cyst there is limited...

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Bibliographic Details
Published in:Journal of biomaterials applications 2013-09, Vol.28 (3), p.343-353
Main Authors: Bulgin, Dmitry, Irha, Ernest, Hodzic, Enes, Nemec, Boris
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Bone Cysts - therapy
Bone marrow
Bone Marrow Transplantation
Bones
Calcium Phosphates - administration & dosage
Child
Collagen - administration & dosage
Cysts
Female
Humans
Lesions
Phosphates
Surgical implants
Tissue Scaffolds
Transplantation, Autologous
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Summary:Aneurysmal bone cyst is a benign, locally destructive lesion of bone. Based on progressive cortical thinning pathological fractures are common, and are often the presenting feature. Despite the long experience of orthopaedists, radiologists and pathologists with aneurysmal bone cyst there is limited knowledge regarding the cause of the lesion and optimal treatment. Common methods of treatment vary considerably in the literature, particularly in children. A large variety of bone substitutes have been used to fill the cystic lesions. To date there has been no graft material which can be regarded as completely satisfactory. Our experience with freshly isolated autologous bone marrow derived mononuclear cells combined with β-tricalcium phosphate and absorbable atelocollagen for bone formation is presented. The concept of this treatment is based on stimulation of natural events continuously present in living bone appear to be a reasonable and beneficial alternative to promote healing of bone cysts and offering both osteoinduction and osteoconductive features.
ISSN:0885-3282
1530-8022
DOI:10.1177/0885328212451047